Results 201 to 210 of about 171,852,411 (303)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Systems medicine: total body positron emission tomography meets omics. [PDF]

Br J Radiol
Jacobs AK, Chan A, Tavares AAS.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Teaching AI for Radiology Applications: a Multisociety-Recommended Syllabus from the AAPM, ACR, RSNA, and SIIM. [PDF]

J Imaging Inform Med
Kitamura F, Kline T, Warren D, Moy L, Daneshjou R, Maleki F, Santos I, Gichoya J, Wiggins W, Bialecki B, O'Donnell K, Flanders AE, Morgan M, Safdar N, Andriole KP, Geis R, Allen B, Dreyer K, Lungren M, Wood MJ, Kohli M, Langer S, Shih G, Farina E, Kahn CE, Reiser I, Giger M, Wald C, Mongan J, Cook T, Tenenholtz N.   +30 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Improving Lipid Screening Adherence in Inflammatory Arthritis Using a Two-Cycle Plan-Do-Study-Act (PDSA) Quality Improvement Intervention. [PDF]

Cureus
Lilly M, Javed M, Jagannath D, Monga K.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Lithuania's National Digital Health System Architecture, Evolution, and Lessons From a Centralized Approach Using Longitudinal Document Analysis: Descriptive National Case Study. [PDF]

JMIR Form Res
Dapkutė A, Niakšu O, Juodakis J, Jankauskienė D, Trinkūnas J, Laurinavičius A, Jovaiša T, Ringaitienė D, Atraškevičienė M, Masiliūnas R.   +9 more
europepmc   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Trends in Pediatric Mental Health-Related Emergency Department Visits During the School Year and School Breaks. [PDF]

J Sch Health
Henderson Smith L, Lyons GR, Hernandez Laines HA, Hendrickson N, Bachert E, Smith M.   +5 more
europepmc   +1 more source