Results 101 to 110 of about 18,351,168 (336)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Jenseits von dem Wir und den Anderen Interreligiöse Perspektiven auf das Othering in der Religionspädagogik

Österreichisches Religionspädagogisches Forum
Der Beitrag widmet sich dem Konzept des Othering in der Religionspädagogik aus evangelischer, katholischer und islamischer Perspektive. Ziel ist es, aufzuzeigen, dass Differenz nicht als Defizit, sondern als pädagogische und theologischeRessource ...
Yağdı, Şenol, Krahn, Annika, Domsel, Maike Maria   +2 more
doaj   +1 more source

Contextual factors, methodological principles and teacher cognition

Studies in Second Language Learning and Teaching, 2014
Teachers in various contexts worldwide are sometimes unfairly criticized for not putting teaching methods developed for the well-resourced classrooms of Western countries into practice.
Rupert Walsh, Mark Wyatt
doaj   +1 more source

Literary representation of Jewish departure in “The Saga of Muziris” by Sethu

RUDN Journal of Studies in Literature and Journalism, 2020
Literature and history are fields of knowledge that cannot have an independent existence. This article aims to analyze the interface of literature and history with reference to the novel “The Saga of Muziris” by Sethu.
Anju Ok
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Otherness and Victimhood in the Tabloid Press: The Case of the “Refugee Crisis” in “Slovenske Novice”

Dve Domovini, 2017
By using critical discourse analysis, the article focuses mainly on ways in which migrants are constructed through language in the most widely-read Slovenian tabloid newspaper, Slovenske novice (Slovenian News).
Andreja Vezovnik
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A Case for Removing Confederate Monuments [PDF]

, 2020
A particularly important, pressing, philosophical question concerns whether Confederate monuments ought to be removed. More precisely, one may wonder whether a certain group, viz.
Timmerman, Travis
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source