Results 121 to 130 of about 163,047 (311)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Continuum Belief, Categorical Belief, and Depression Stigma: Correlational Evidence and Outcomes of an Online Intervention [PDF]

open access: yes, 2019
Continuum belief interventions that erode boundaries between “normal” individuals and individuals with psychiatric problems may help to reduce psychiatric stigma, but a number of questions persist.
Thibodeau, Ryan
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Constructing the other: managerial rhetorics of diversity. [PDF]

open access: yes
In this article, we examine how HR managers rhetorically construct diversity as discourses of Otherness. Our analysis relies on argument schemes developed by the classical rhetoric tradition.
Janssens, Maddy, Zanoni, Patrizia
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Critical dialogues: slow readings of English literary texts [PDF]

open access: yes, 2011
The reader will find gathered together in this volume a selection of articles and essays that have been separately published over the past three decades as a result of my teaching practice and research activity. In chronological terms, they span a period
Correia, Maria Helena de Paiva, 1944-   +1 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Visions of China: Avant-Orientalism, Art Rock, and Conflicted Otherness

open access: yesCinéma & Cie, 2019
The essay reexamines the countercultural positionality of art rock musical works by considering the often-dismissed correlations between Western rock and the Oriental. Introducing the concept of Orientalism to Lawrence Grossberg’s five- hypothesis
Gabriele
doaj  

[Review of] Jennifer S.H. Brown and Robert Brightman. The Orders of the Dreamed :George Nelson on Cree and Northern Ojibwa Religion and Myth, 1823 [PDF]

open access: yes, 1989
This text addresses the complex challenge of comprehending religious otherness. Brown and Brightman present a previously unpublished 1823 letter journal of fur trader George Nelson in which he reflects on his struggle to understand the Cree and Ojibwa ...
Morrison, Kenneth M.
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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