Three-dimensionally visualized ossification and mineralization process of the otic capsule in a postnatal developmental mouse [PDF]
Laryngoscope Investigative Otolaryngology, 2023 Objective We aimed to elucidate the ossification process of the otic capsule in postnatal C57BL/6 mice and depict the three‐dimensional (3D) process of otoconial mineralization in vivo. Methods The otic capsules of C57BL/6 mice were stained with alizarin
Takeshi Tsutsumi +2 more
exaly +3 more sources
Why should multiple dehiscences of the otic capsule be considered before surgically treating patients with superior semicircular canal dehiscence? A radiological monocentric review and a case series [PDF]
Frontiers in Neurology, 2023 This review aims to draw attention to the multiple ipsilateral otic capsule dehiscences (OCDs), which may cause therapeutic failure in operated patients.
Hung Thai-Van +2 more
exaly +4 more sources
CCDC154 Mutant Caused Abnormal Remodeling of the Otic Capsule and Hearing Loss in Mice [PDF]
Frontiers in Cell and Developmental Biology, 2021 Osteopetrosis is a rare inherited bone disease characterized by dysfunction of osteoclasts, causing impaired bone resorption and remodeling, which ultimately leads to increased bone mass and density.
Kai Xu +6 more
doaj +2 more sources
Otic Capsule Dehiscences Simulating Other Inner Ear Diseases: Characterization, Clinical Profile, and Follow-Up—Is Ménière’s Disease the Sole Cause of Vertigo and Fluctuating Hearing Loss? [PDF]
Audiology ResearchIntroduction: We present a series of six cases whose clinical presentations exhibited audiovestibular manifestations of a third mobile window mechanism, bearing a reasonable resemblance to Ménière’s disease and otosclerosis. The occurrence of these cases
Joan Lorente-Piera +5 more
doaj +2 more sources
Extensive Cochlear Otosclerosis: CT-MRI Correlation and the Diagnostic Value of Contrast Enhancement [PDF]
DiagnosticsOtosclerosis is a chronic disorder of the otic capsule. It is characterized by abnormal bone remodeling, which may extend beyond the fenestral region and involve the cochlea and other structures of the bony labyrinth.
Roberts Tumeļkāns +2 more
doaj +2 more sources
Temporal Bone Fractures on High-Resolution CT: Bridging Radiologic Detail with Otologic Anatomy and Surgical Implications [PDF]
DiagnosticsPrimary Objective: To characterize high-resolution computed tomography (HRCT) fracture patterns, namely orientation and otic capsule status, among Sudanese patients with acute temporal bone trauma. Secondary Objectives: (i) To quantify the prevalence and
Osama M. K. Edris +9 more
doaj +2 more sources
Biodistribution and transport of intratympanically administered drugs in the inner ear using a porcine ex-vivo chamber model [PDF]
Materials & DesignEffective pharmacotherapy for hearing loss remains a significant challenge because of the blood-labyrinth barrier, which limits systemic drug access and often necessitates local intratympanic (IT) administration.
Farimah Moazzam +5 more
doaj +2 more sources
Audiologic Patterns of Otic Capsule Preserving Temporal Bone Fracture: Effects of the Affected Subsites [PDF]
Clinical and Experimental Otorhinolaryngology, 2016 Objectives. This study was aimed to assess the relationship between the type of temporal bone area involved and conductive hearing loss. Methods. We enrolled 97 patients who visited the otolaryngology clinics of Seoul National University Hospital or ...
So Young Kim +3 more
doaj +2 more sources
Post‐Traumatic Cochlear and Vestibular Pneumolabyrinth [PDF]
Clinical Case ReportsCochlear pneumolabyrinth is a strong radiologic marker of irreversible hearing loss after otic capsule trauma. While vestibular symptoms may resolve spontaneously, cochlear air reliably predicts poor auditory recovery.
Santiago Almanzo +6 more
doaj +2 more sources
Audiometric and vestibular outcomes following temporal bone fractures: a retrospective analysis of a major trauma center cohort in China [PDF]
Frontiers in MedicineBackgroundTemporal bone fractures form a major skull-base injury subset, yet prognostic data—drawn chiefly from short-term Western cohorts—remain sparse.
Caijuan Wu, Qiang He
doaj +2 more sources