Results 251 to 260 of about 161,394 (344)

Metformin Treatment in PCOS Pregnancies Reduces Maternal Infections and Increases the Risk of Allergies and Eczema in the Offspring: Post Hoc Analyses of Two Randomised Controlled Trials and One Follow‐Up Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 132, Issue 12, Page 1823-1832, November 2025.
ABSTRACT Objective To evaluate the effect of metformin on immunological outcomes in pregnant women with polycystic ovary syndrome (PCOS) and their offspring. Design Post hoc analyses of two randomised controlled trials (PregMet and PregMet2) and one follow‐up study (PedMet).
Mariell Ryssdal, Johanne E. Skage, Anders H. Jarmund, Liv Guro E. Hanem, Tone S. Løvvik, Guro F. Giskeødegård, Ann‐Charlotte Iversen, Eszter Vanky   +7 more
wiley   +1 more source

The Aetiology of Elevated Total Serum Immunoglobulin E in Children

Acta Paediatrica, Volume 114, Issue 11, Page 2993-2999, November 2025.
ABSTRACT Aim The paucity of real‐world data on the aetiology of elevated total serum immunoglobulin E (TS‐IgE) in children afflicts families and health care systems with diagnostic uncertainty. We explored a cohort of children with TS‐IgE levels over 1000 kU/L, focusing on the prevalence of atopic and non‐atopic conditions, the aetiology of extremely ...
Aliisa Ärölä, Kaarina Kukkonen, Svetlana Vakkilainen   +2 more
wiley   +1 more source

Prevalence of Cholesteatoma in School Children of Nepal. [PDF]

Int Arch Otorhinolaryngol
Maharjan M, Rajbhandari S, Subba S, Gupta A.   +3 more
europepmc   +1 more source

Risk Factors for Hearing Loss Are Comparable in Preterm Versus Term Children: A Systematic Review

Acta Paediatrica, Volume 114, Issue 11, Page 2763-2782, November 2025.
ABSTRACT Aim Hearing loss occurs more frequently in preterm children. However, the influence of prematurity itself is unclear. We examined whether risk factors for hearing loss differ between preterm and term infants. Methods We conducted a systematic search of three databases in March 2023 for studies comparing risk factors for hearing loss in preterm
Pauline Roehrs, Anna‐Katharina Rohlfs, Reinhard Vonthein, Camilla Simon, Juliane Spiegler   +4 more
wiley   +1 more source

SARS-CoV-2 infection in pregnancy and infant outcomes in the first year of life: a retrospective cohort study. [PDF]

BMC Pediatr
Wong K, Ducharme R, Murphy MSQ, Clarke AE, Brophy J, Hawken S, El-Chaâr D.   +6 more
europepmc   +1 more source

Case Report: Association of Ocular Colobomas With a Novel Missense Variant in CDC42, a Member of the Rho Family of Small GTPases

Clinical Genetics, Volume 108, Issue 5, Page 589-593, November 2025.
We report a 2‐year‐old male with clinical features of Takenouchi‐Kosaki syndrome, bilateral colobomas, and a de novo, likely pathogenic missense variant in CDC42. Supportive evidence includes a Cdc42 conditional knock‐out mouse model with colobomas.
Diana Brightman, Nawaal Shinwari, Aleksey Porollo, Eniolami O. Dosunmu, Ehsan Ullah, Bin Guan, Robert B. Hufnagel, Brian P. Brooks, Delphine Blain, Sabine Fuhrmann, Brittany Simpson, Anne M. Slavotinek   +11 more
wiley   +1 more source

Case Report: A rare case of tuberculous otitis media mimicking chronic suppurative otitis media - an ongoing challenge. [PDF]

Front Med (Lausanne)
Shu C, You T, Huang M, Xu M, Zhang J, Peng Z.   +5 more
europepmc   +1 more source

Clinical and Neurodevelopmental Characteristics of Paralogous Gain‐of‐Function Variants at GRIA2 p.Gly792 and GRIA3 p.Gly803

Clinical Genetics, Volume 108, Issue 5, Page 553-565, November 2025.
Key features of paralogous GRIA2 and GRIA3 gain‐of‐function variants. ABSTRACT GRIA‐related disorders arise from disease‐causing variants in GRIA1, GRIA2, GRIA3, or GRIA4 that encode α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazole propionic acid (AMPA)‐type glutamate receptors (AMPARs).
Emilie Sjøstrøm, Dorota Studniarczyk, Xinyao Dou, Rebekka S. Dahl, Vincent Cruz, Heng Wang, Sandra Mercier, Wallid Deb, Thomas Besnard, Jennifer Friedman, Miriam Essid, Sana Karoui, Lamia Ben Jemaa, Thouraya Benyounes, Gaetan Lesca, Davide Tonduti, Maria Iascone, Simona Orcesi, Melanie Fradin, Christèle Dubourg, Silvia Napuri, Stuart G. Cull‐Candy, Ian D. Coombs, Mark Farrant, Allan Bayat   +24 more
wiley   +1 more source