Results 61 to 70 of about 163,596 (354)

A Phase 1 Study of the Pharmacokinetics, Safety, and Tolerability of Posdinemab (JNJ‐63733657) in Healthy Chinese Adults

The Journal of Clinical Pharmacology, EarlyView.
Abstract Posdinemab, a humanized immunoglobulin G1/κ monoclonal antibody, binds with high affinity to phosphorylated tau protein which is associated with Alzheimer's disease (AD) pathophysiology. Posdinemab reduced tau seeding in murine models and was well tolerated in Phase‐1 clinical studies.
Fangfang Wang, Juanfang Liu, Daisy Bai, Lingjue Li, Maggie Fedgchin, David Henley, Haiyan Li, Fan Zhang   +7 more
wiley   +1 more source

Characteristics of Adult Patients With Atopic Dermatitis Initiating Biologics and Janus Kinase Inhibitors in the CorEvitas Atopic Dermatitis Registry

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Biologics and Janus kinase inhibitors (JAKi) are two advanced systemic treatment options for patients with atopic dermatitis (AD). The decision to initiate one of these therapies is complex and may be driven by many factors.
Eric L. Simpson, Linda Stein Gold, Seemal R. Desai, Alexandra K. Golant, Douglas DiRuggiero, Christian Fenske, Yolanda Muñoz Maldonado, Alvin H. Li, Zach Dawson, Kaylee Ho, Kayla Callahan, Gaia Gallo, Jonathan I. Silverberg   +12 more
wiley   +1 more source

A STUDY ON CHRONIC OTITIS MEDIA ACTIVE MUCOSAL TYPE WITH SINUSITIS AS FOCAL SEPSIS [PDF]

, 2012
AIM : To establish the role of Sinusitis as Focal sepsis in Chronic Otitis media active mucosal disease, to emphasizethe need of proper diagnostic endoscopic evaluation and improvement in middle ear mucosal disease status afterfunctional endoscopic sinus
Gopalakrishnan, Shankaranarayanan, Kumar, Sathish   +1 more
core   +1 more source

Shared decision making and antibiotic benefit-harm conversations: an observational study of consultations between general practitioners and patients with acute respiratory infections [PDF]

, 2018
Background Little research has examined whether shared decision making (SDM) occurs in consultations for acute respiratory infections (ARIs), including what, and how, antibiotic benefits and harms are discussed.
Bakhit, Mina, Del Mar, Chris, Gibson, Elizabeth, Hoffmann, Tammy   +3 more
core   +4 more sources

Otitis media [PDF]

The Lancet, 2004
Otitis media (OM) continues to be one of the most common childhood infections and is a major cause of morbidity in children. The pathogenesis of OM is multifactorial, involving the adaptive and native immune system, Eustachian-tube dysfunction, viral and bacterial load, and genetic and environmental factors. Initial observation seems to be suitable for
Rovers, M.M., Schilder, A.G.M., Zielhuis, G.A., Rosenfeld, R.M.   +3 more
openaire   +2 more sources

Increased Risk of Cholesteatoma in Individuals With Alpha‐1 Antitrypsin Deficiency: A Cohort Study

The Laryngoscope, EarlyView.
Patients with AATD had a 3.6‐fold increased risk of cholesteatoma surgery (HR: 3.62) compared to controls. These findings suggest that AATD may contribute to the development of cholesteatoma. ABSTRACT Objective To estimate the risk of cholesteatoma in patients with alpha‐1 antitrypsin deficiency (AATD) compared to the general population using time‐to ...
Abdulla Ali, Helene Andresen Ravn, Morten Dahl, Bjarki Ditlev Djurhuus   +3 more
wiley   +1 more source

Fusobacterium necrophorum, an emerging pathogen of otogenic and paranasal infections?

New Microbes and New Infections, 2014
Fusobacterium necrophorum is a rare causative agent of otitis and sinusitis. Most commonly known is the classic Lemièrre's syndrome of postanginal sepsis with suppurative thrombophlebitis of the jugular vein.
D. Creemers-Schild, F. Gronthoud, L. Spanjaard, L.G. Visser, C.N.M. Brouwer, E.J. Kuijper   +5 more
doaj   +1 more source

Demography and disorders of German Shepherd Dogs under primary veterinarycare in the UK [PDF]

, 2017
The German Shepherd Dog (GSD) has been widely used for a variety of working roles. However, concerns for the health and welfare of the GSD have been widely aired and there is evidence that breed numbers are now in decline in the UK.
A Agresti, A Egenvall, A Gough, A Kathrani, A Kyriazis, A Peiravan, AJ German, AK Hielm-Björkman, AL Holder, AR Michell, BR Kirkwood, C Kraus, C Selman, CE Griffin, D Clements, D O'Neill, DG O'Neill, DG O'Neill, DG O'Neill, DJ Batchelor, E O'Sullivan, E Sturaro, E Westermarck, EL Buckland, EM Lund, EM Lund, F Galis, G Diesel, GJ Patronek, GK Smith, H Abdi, HE Salvin, J Fatjo, J Summers, JF Summers, JM Dobson, JM Fleming, JM Wahl, JMR Cornelissen, JP Genevois, K Svartberg, K Svartberg, KA Gershman, KA Greer, KE Bergvall, KL Overall, L Asher, L Asher, LJ Kennedy, LM Collins, LM Collins, M Downes, M Petazzoni, MI Benninger, N Ondreka, N Pearce, N Rooney, NJ Robinson, NJ Rooney, P Bateson, P Saetre, P Sandøe, R Packer, R Zeng, RMA Packer, S Breit, SR Urfer, TH Witsberger, VJ Adams, Å Vilson   +69 more
core   +1 more source

18‐FDG PET in the Evaluation of Therapeutic Response of Necrotizing Otitis Externa

The Laryngoscope, EarlyView.
PET performed well in assessing the therapeutic response of NEO, with excellent sensitivity but low specificity of visual analysis. A complementary quantitative analysis was useful to distinguish between satisfactory and insufficient partial responses. ABSTRACT Objective The duration of antibiotic treatment for necrotizing otitis externa (NEO) and the ...
Lucie Lécolier, Philippine Toulemonde, Damien Huglo, Clio Baillet, Pauline Thill, Gauthier Delaby   +5 more
wiley   +1 more source

Perfil de susceptibilidad bacteriana en cepas de Staphylococcus spp. aislados de caninos con otitis externa

Revista Científica
La otitis externa es una inflamación del conducto auditivo externo, que afecta generalmente a los caninos, sus causas pueden ser múltiples. El objetivo de la presente investigación fue determinar el perfil de susceptibilidad bacteriana en cepas de ...
Robert Gustavo Sánchez–Prado, Joseline Paola Santo–Endara, Raquel Estefania Sánchez–Prado, Samantha Guzmán–Pucha, Fernando Lenin Aguilar–Gálvez, Lorena Elizabeth Chalco–Torres, Dioselina Esmeralda Pimbosa–Ortiz, Jhonny Edgar Pérez–Rodriguez   +7 more
doaj   +1 more source