Results 41 to 50 of about 16,377 (192)

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh   +5 more
wiley   +1 more source

DISTORTION PRODUCT OTOACOUSTIC EMISSIONS IN NORMAL - HEARING WORKERS EXPOSED TO OCCUPATIONAL NOISE [PDF]

open access: yesRevista Gestão & Saúde, 2013
Introduction-The otoacoustic emissions test has been highlighted by thepossibility of detecting early cochlear changes resulting from exposureto noise, not identifiedby audiometry.Objective: To evaluate the distortion product otoacoustic emissions ...
Marlene Escher Boger   +2 more
doaj  

Waves on Reissner's Membrane: A Mechanism for the Propagation of Otoacoustic Emissions from the Cochlea

open access: yesCell Reports, 2012
Sound is detected and converted into electrical signals within the ear. The cochlea not only acts as a passive detector of sound, however, but can also produce tones itself.
Tobias Reichenbach   +3 more
doaj   +1 more source

Otoacoustic emission measurements: a test–retest reliability study

open access: yesThe Egyptian Journal of Otolaryngology, 2023
Objectives Otoacoustic emissions (OAEs) are an important part of the audiological test battery and have many clinical uses. This study aims to determine the amplitude changes in the test–retest condition of distortion product otoacoustic emissions ...
Ayşenur Aykul Yağcıoğlu   +1 more
doaj   +1 more source

Audiovestibular functioning of post-menopausal females with osteoporosis and osteopenia

open access: yesJournal of Otology, 2021
Introduction: Osteoporosis and osteopenia are progressive disorders characterized by decreased bone mass, especially in postmenopausal women. These can be associated with body pain, fractures, hearing loss and balance disorders. The present study aims to
Manisha K. Juneja   +4 more
doaj   +1 more source

Cochlear-bone wave can yield a hearing sensation as well as otoacoustic emission

open access: yes, 2014
A hearing sensation arises when the elastic basilar membrane inside the cochlea vibrates. The basilar membrane is typically set into motion through airborne sound that displaces the middle ear and induces a pressure difference across the membrane.
Reichenbach, T., Tchumatchenko, T.
core   +1 more source

Brainstem auditory evoked responses in an equine patient population: part I--adult horses. [PDF]

open access: yes, 2014
BackgroundBrainstem auditory evoked response has been an underused diagnostic modality in horses as evidenced by few reports on the subject.Hypothesis/objectivesTo describe BAER findings, common clinical signs, and causes of hearing loss in adult horses ...
Aleman, M   +3 more
core   +1 more source

Mesna in Otologic Surgery: Efficacy and Safety—A Scoping Review

open access: yesThe Laryngoscope, EarlyView.
PRISMA flow diagram indicating the process of systematic inclusion and exclusion of articles. ABSTRACT Objective Mesna (Sodium 2‐mercaptoethanesulfonate) is widely used as a mucolytic agent and uroprotective agent. Recently, its disulfide bond‐breaking property has been applied in otologic surgery to facilitate safer dissection of cholesteatoma and ...
Kevork H. Atamian   +4 more
wiley   +1 more source

Sensory hyperacusis as a predictor of anxiety in adolescence

open access: yesJournal of Child Psychology and Psychiatry, EarlyView.
Background An increasing number of children report anxiety in early to mid‐adolescence. Early identification of risk during the transition from primary to secondary schools (age 11) could enhance family‐ or school‐based interventions. While known predictors of adolescent anxiety provide some insight, there is a need to identify and understand ...
Foteini Tseliou   +3 more
wiley   +1 more source

Ototoxicity and otoprotection in the inner ear of guinea pigs using gentamicin and amikacin: ultrastructural and functional aspects

open access: yesBrazilian Journal of Otorhinolaryngology, 2008
Summary: Ototoxicity is still a challenge to medicine. The discovery of self-protecting endogenous mechanisms of the outer hair cells associated with their functional and ultra-structural assessment methods has opened new horizons in the understanding ...
Thomaz José Marra de Aquino   +2 more
doaj   +1 more source

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