Results 71 to 80 of about 182,731 (328)

CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang, Fen Chang, Zinan Li, Chengcheng Duan, Xiangkai Sun, Siyu Wang, Dongmin Wei, Wenming Li, Ye Qian, Shengda Cao, Juan Zhao, Dapeng Lei   +11 more
wiley   +1 more source

Risk Factor Analysis for 30-Day Readmission Rates of Newly Tracheostomized Children [PDF]

, 2017
Objectives: Pediatric patients undergo tracheostomy for a variety of reasons; however, medical complexity is common among these patients. Although tracheostomy may help to facilitate discharge, these patients may be at increased risk for hospital ...
Barth, MD, Patrick, Briddel, MD, Jenna, Chidekel, MD, Aaron, Levi, MD, Jessica, Shah, MD, Udayan, Strang, MD, Abigail   +5 more
core   +1 more source

Label‐Free 3D Photoacoustic Imaging of Tumor Organoids for Volumetric Drug Screening

Advanced Science, EarlyView.
A label‐free organoid photoacoustic imaging (LFOPI) system is developed for precise volumetric drug screening evaluation. As a proof of concept, LFOPI's performance in chemotherapy and immunotherapy drug screening assays are further evaluated. The LFOPI offers unique non‐invasive, label‐free capabilities for tumor organoids, and contributes to the ...
Xiaofei Luo, Maike Chen, Han Shan, Xize Yu, Qibo Lin, Qian Tao, Xiongwei Wei, Changling Lv, Ziyan Chen, Fan Zhuo, Xi Zhu, Jiaxing He, Zhaoxi Li, Chunlong Fei, Jing Xu, Juan Su, Zeyu Chen, Shuang Zhao, Xiang Chen   +18 more
wiley   +1 more source

Pathological margins and advanced cutaneous squamous cell carcinoma of the head and neck. [PDF]

, 2019
OBJECTIVE:The recommended treatment for cutaneous squamous cell cancer (CuSCC) of the head and neck is Mohs surgical excision or wide local excision. Excision is recommended to a gross surgical margin of 4-6 mm however this is based on limited evidence ...
Bewley, AF, Farwell, DG, Harris, BN, Moore, MG, Phillips, TJ   +4 more
core   +1 more source

Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery

Advanced Science, EarlyView.
Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai, Shasha Zhang, Mingchen Dai, Pei Jiang, Jingyuan Huang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Jun He, Qiuyue Mao, Yintao Wang, Zixuan Ye, Tian Wang, Renjie Chai   +14 more
wiley   +1 more source

Variations in concerns reported on the Patient Concerns Inventory (PCI) in head and neck cancer patients from different health settings across the world [PDF]

, 2019
Background: The aim was to collate and contrast patient concerns from a range of different head and neck cancer follow-up clinics around the world. Also, we sought to explore the relationship, if any, between responses to the patient concerns inventory ...
Alvear, Alvaro, Anesi, Alexandre, Babin, Emmanuel, Balik, Ali, Batstone, Martin, Brockmeyer, Phillipp, Carrasco, Claudia Celedon, Chien, Chih-Yen, Chirila, Magdalena, Dholam, Kanchan P, Doss, Jennifer G, Ehrsson, Ylva Tiblom, Finizia, Caterina, Ghani, Wan M Nabilah, Gurav, Sandeep V, Kadir, Kathreena, Kolator, Mateusz, Lara, Pablo Vasquez, Lima, Roberto, Lin, Yu-Tsai, Lowe, Derek, Nhongo, Simon, Ozdemir-Karatas, Meltem, Peker, Kadriye, Pesic, Zoran, Ransy, Pierre, Rogers, Simon N, Santos, Izabella, Schliephake, Henning, Shah, Ketan, Souza, Fernanda, Sunil, Geethu, Thankappan, Krishnakumar, Tiple, Cristina, Tuomi, Lisa, Valerini, Sara, Zato\u144ski, Tomasz   +36 more
core   +2 more sources

Significant linkage at chromosome 19q for otitis media with effusion and/or recurrent otitis media (COME/ROM)

BMC Medical Genetics, 2011
Background In previous analyses, we identified a region of chromosome 19 as harboring a susceptibility locus for chronic otitis media with effusion and/or recurrent otitis media (COME/ROM).
Chen Fang, Mychaleckyj Josyf C, Allen E Kaitlynn, Chen Wei-Min, Hou Xuanlin, Rich Stephen S, Daly Kathleen A, Sale Michèle M   +7 more
doaj   +1 more source

Targeting Neutrophil/Eosinophil Extracellular Traps by Aptamer‐Functionalized Nanosheets to Overcome Recalcitrant Inflammatory Disorders

Advanced Science, EarlyView.
In this study, C‐TAH, as multifunctional nanosheets, is developed with tannic acid and histone aptamer coverage. C‐TAH displays mild cytotoxicity, robust dsDNA and NETs/EETs binding efficiency, and potent antioxidant and antibacterial ability in vitro. C‐TAH treatment ameliorates dysregulated inflammation and restores hearing function in animal models,
Yongqiang Xiao, Xinyue Wang, Ming Liu, Xiao Fu, Nanfeng Zhang, Wenqing Yang, Junyi Ge, Yangyang Li, Duan Ma, Jing Ma, Weiping Wen, Dongdong Ren, Tianyu Zhang, Zhaoxu Tu   +13 more
wiley   +1 more source

The role of external broadcasting in a closed political system [PDF]

, 2011
This article investigates the role and impact of external broadcasting (radio and television) on a closed political system, through the example of the two post-war German states: the West German Federal Republic of Germany (FRG) and the East German ...
Andreas Scheu, Browne DR, Castells M., Corbin J., DeFleur ML, Der Spiegel, Hafez K., Hahn O., Hesse KR, Hopkins M., Hyman HH, Infratest, Infratest, Infratest, Infratest, Jansen M., Lindlof T., McQuail D., Merritt AJ, Merritt AJ, Meyen M., Michael Meyen, Parta RE, Perse EM   +23 more
core   +2 more sources

LncRNA TMEM99 Complexes with IGF2BP2 to Inhibit Autophagy in Lung Adenocarcinoma

Advanced Science, EarlyView.
LncRNA TMEM99 is significantly upregulated in lung adenocarcinoma (LUAD) and correlates with poor prognosis. It promotes LUAD cell proliferation, migration, and invasion while suppressing autophagy. Mechanistically, TMEM99 binds FUBP3 and recruits IGF2BP2 in an m⁶A‐dependent manner to stabilize and enhance p21 mRNA translation, uncovering a novel ...
Zhigang Wu, Yue Zhao, Yizhou Peng, Pengcheng Liu, Qixuan Huang, Yang Wo, Yunjian Pan, DongDong Zheng, Chongze Yuan, Yan Shang, Xiao Chen, Hui Hong, Yihua Sun   +12 more
wiley   +1 more source