Results 51 to 60 of about 2,602 (246)

The role and regulatory mechanism of lysosome associated protein transmembrane 4β in tumors

Frontiers in Oncology
The oncogene LAPTM4B (encoding lysosome-associated protein transmembrane-4β), first cloned in hepatocellular carcinoma cells, is located on chromosome 8q22.1 and encodes two isoforms, LAPTM4B-35 and LAPTM4B-24.
Yuteng Yang, Yuteng Yang, Yuteng Yang, Yuteng Yang, Yuteng Yang, Yumei Li, Yumei Li, Yumei Li, Yumei Li, Yaqi Wang, Yaqi Wang, Yaqi Wang, Yaqi Wang, Xi Chen, Xi Chen, Xi Chen, Xi Chen, Yisong Yao, Yisong Yao, Yisong Yao, Yisong Yao, Dongxian Li, Dongxian Li, Dongxian Li, Dongxian Li, Guohua Yu, Guohua Yu, Guohua Yu, Guohua Yu, Xicheng Song, Xicheng Song, Xicheng Song, Xicheng Song   +32 more
doaj   +1 more source

Primary Ciliary Dyskinesia: An Update on Clinical Aspects, Genetics, Diagnosis, and Future Treatment Strategies [PDF]

, 2017
Primary ciliary dyskinesia (PCD) is an orphan disease (MIM 244400), autosomal recessive inherited, characterized by motile ciliary dysfunction. The estimated prevalence of PCD is 1:10,000 to 1:20,000 live-born children, but true prevalence could be even ...
Abete, Afzelius, Afzelius, Afzelius, Alanin, Altenburg, Bartoloni, Behan, Bhatt, Bilton, Boaretto, Boe, Boon, Boon, Boon, Bradley, Brenner, Brown, Bush, Bush, Campbell, Carotenuto, Chang, Chang, Chernick, Cohen-Cymberknoh, Cole, Coren, Davis, Daviskas, De Benedetti, Desai, Deuse, Eastham, El-Abiad, Eliasson, Elkins, Ellerman, Fedakar, Ferkol, Ferkol, Fliegauf, Fliegauf, Flume, Fokkens, Fretzayas, Frommer, Fuchs, Gokdemir, Goutaki, Halbert, Hart, Hellinckx, Hill, Horani, Horani, Irving, Jeanson, Kartagener, Kellett, Kennedy, Kennedy, Kennedy, Kim, King, Knowles, Knowles, Knowles, Kobbernagel, Konstan, Kott, Kuehni, Kumar, Lai, Lebl, Leigh, Lucas, Lucas, Lucas, Lucas, Macchiarini, Mackerness, Madsen, Maglione, Maglione, Manna, Marks, Marthin, Marthin, Marthin, Mateos-Corral, McManus, Merveille, Mirra, Mitchison, Montella, Montella, Montella, Montella, Moore, Mossberg, Mullowney, Munro, Nakhleh, Nicolson, Noone, Noone, Oktem, Olbrich, Omran, Onoufriadis, Onoufriadis, O’Callaghan, O’Callaghan, Paff, Paff, Papon, Pasteur, Patella, Phillips, Picot, Pifferi, Potter, Prulière-Escabasse, Raidt, Rogers, Rutland, Sagel, Santamaria, Santamaria, Schwabe, Serisier, Shah, Shapiro, Shoemark, Sommer, Spagnolo, Stenbit, Stillwell, Sturgess, Svobodova, ten Berge, Valerio, Walker, Wallmeier, Werner, Werner, Wirschell, Wong, Yan-Wei, Zimmerman   +150 more
core   +1 more source

Taste and Smell Disorders in Children and Young Adults With Cystic Fibrosis and Primary Ciliary Dyskinesia—A Prospective Comparative Study

Pediatric Pulmonology, Volume 60, Issue 12, December 2025.
ABSTRACT Background In cystic fibrosis (CF), the defect of the CF transmembrane conductance regulator (CFTR) can also affect sensory nerve cell function, as recently demonstrated in animal models. The aim of this prospective cohort study was to investigate whether taste and smell disorders in CF correlate with persistent CFTR dysfunction detectable by ...
Lea Christiane Beermann, Lisa Sophie Demski, Lynn Eitner, Stefanie Dillenhöfer, Anne Schlegtendal, Claire Mallon, Folke Brinkmann, Christoph Maier, Thomas Lücke, Anna Teresa Hoffmann   +9 more
wiley   +1 more source

Characteristics and outcome of Streptococcus pneumoniae endocarditis in the XXI Century: a systematic review of 111 cases (2000-2013) [PDF]

, 2017
Streptococcus pneumoniae is an infrequent cause of severe infectious endocarditis (IE). The aim of our study was to describe the epidemiology, clinical and microbiological characteristics, and outcome of a series of cases of S. pneumoniae IE diagnosed in
Alarcón, Aristides de, Bouza, Emilio, Egea, Viviana de, Fariñas, María Carmen, Garcia Pavia, Pablo, García Vázquez, Elisa, Goenaga Sánchez, Miguel Ángel, Gálvez-Acebal, Juan, Lepe, José Antonio, Marín, Mercedes, Miró Meda, José M., Moreno Camacho, Ma. Asunción, Muñoz, Patricia, Navas Pérez, Enrique, Sitges Carreño, Marta, Valerio, Maricela   +15 more
core   +1 more source

Looking at Burning Mouth Syndrome Brain: The Prevalence of Idiopathic Intracranial Hypertension Radiologic Signs in BMS Patients

Journal of Oral Rehabilitation, Volume 52, Issue 11, Page 2095-2101, November 2025.
Prevalence of radiologic signs of idiopathic intracranial hypertension in burning mouth syndrome patients. ABSTRACT Background Idiopathic intracranial hypertension (IIH), a disorder characterised by an elevation of intracranial pressure, has implications in chronic pain syndromes, especially in the cranial territory, and has been a matter of discussion.
Michele Davide Mignogna, Noemi Coppola, Stefania Leuci, Mattia Sansone, Federica Canfora, Daniela Adamo, Roberto De Simone   +6 more
wiley   +1 more source

Solitary frontal ulcer: A syphilitic gumma [PDF]

, 2010
We report the case of a 30-year-old woman presenting with a single, deep, asymptomatic frontal ulcer that had developed in the previous two months without preceding trauma.
Andrade, P, Figueiredo, A, Mariano, A
core   +1 more source

Prevalence and psychopathological characteristics of depression in consecutive otorhinolaryngologic inpatients [PDF]

, 2011
Background High prevalence of depression has been reported in otorhinolaryngologic patients (ORL). However, studies using a semi-structured interview to determine the prevalence of depression in ORL are lacking.
A Kugaya, A Verdelho, A Wasan, AD Sadovnick, AJ Stunkard, AT Beck, B Bankier, B Rudisch, C Norra, Christine Norra, CL DeVane, CL Raison, DE Bush, DG Cruess, DL Evans, Eftychia Volz-Sidiropoulou, H Bronheim, HU Wittchen, J Cohen, J Hellgren, J Mace, JS Abramowitz, LR Derogatis, LR Derogatis, LV Hedges, Maren Boecker, Markus Wirtz, Martin Westhofen, N Bhattacharyya, P Waraich, R Brandsted, RC Kessler, RG Robinson, RK Chandra, S Singer, Siegfried Gauggel, T Forkmann, T Forkmann, Thomas Forkmann, Thomas Vehren, W Hiller, World Health Organization, World Medical Association, WP Dunlap   +43 more
core   +3 more sources

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, Volume 12, Issue 40, October 27, 2025.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Karyopatologic changes in buccal epithelium cells of the people, who suffer diseases from otorhinolaryngologic spher [PDF]

, 2017
This work consisted in the study of karyopatologic changes in buccal epithelium of the people, who suffer different otolaryngologic diseases: chronic tonsillitis, acute nasopharyngitis, chronic vasomotor rhinitis and chronic rhinosinusitis.
Гороховский, А. А., Котова, В. Н., Ханьжин, М. С.   +2 more
core  

Expanding the Spectrum: A Rare Case of Morquio Syndrome With Bronchial Asthma and Seizure Disorder

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT This case highlights a rare co‐existence of Morquio syndrome with bronchial asthma and myoclonic seizures, expanding the known clinical spectrum. It emphasizes the need for comprehensive, multidisciplinary management to address multisystem involvement and describes the challenges of treatment in resource‐limited settings where advanced ...
Bijay Bastola, Sweekar Dahal, Ramesh Raj Acharya, Manish Sah, Pratisma Wagle   +4 more
wiley   +1 more source