Results 51 to 60 of about 93,275 (265)

A Hypoxia‐Responsive Single‐Atom Sonozyme for Targeted Sonocatalytic Therapy in Alleviating Atherosclerotic Plaque

Advanced Science, EarlyView.
A tetranitrogen‐coordinated single‐atom manganese catalyst (SMC) is fabricated with outstanding sonosensitization efficiency and multi‐enzyme‐like catalytic properties. To enable better targeting of M1 macrophages, hyaluronic acid (HA) is applied to modify the surface of SMC, yielding SMC‐HA nanozymes.
Qiaofei Chen, Guotao Yuan, Zhiwen Liu, Zhengyu Cao, Li He, Ruonan Li, Tongsheng Huang, Minglong Zheng, Kexin Wen, Canxia Huang, Shuang Zhu, Pingyu Zhang, Jingfeng Wang, Yuling Zhang, Yue Pan   +14 more
wiley   +1 more source

Analysis of prevalence, aetio-pathology of tinnitus and role of caroverine as a primary treatment option among the patients attending a tertiary care hospital [PDF]

Al Ameen Journal of Medical Sciences
Background: Tinnitus, characterized by the perception of sound in the absence of an external stimulus, is increasingly prevalent in ENT practice across India.
Alfisha Sulthana, Abhilash Reddy, S. Muneeruddin Ahmed, Shahul Hameed, S. Abida Ashroff Fathima   +4 more
doaj  

The Role of Inflammation-Associated Factors in Head and Neck Squamous Cell Carcinoma

Journal of Inflammation Research, 2023
Kang Li,1,2,* Xianhai Zeng,1,2,* Peng Liu,1,2 Xiaoxia Zeng,2 Jie Lv,3 Shuqi Qiu,1,2 Peng Zhang1,2 1Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai Campus, Zhuhai, Guangdong, People’s Republic of China; 2Department ...
Li K, Zeng X, Liu P, Zeng X, Lv J, Qiu S, Zhang P   +6 more
doaj  

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Towards Precision Medicine in Sinonasal Tumors: Low-Dimensional Radiomic Signature Extraction from MRI

Diagnostics
Background: Sinonasal tumors are rare, accounting for 3–5% of head and neck neoplasms. Machine learning (ML) and radiomics have shown promise in tumor classification, but current models lack detailed morphological and textural characterization.
Riccardo Biondi, Giacomo Gravante, Daniel Remondini, Sara Peluso, Serena Cominetti, Francesco D’Amore, Maurizio Bignami, Alberto Daniele Arosio, Nico Curti   +8 more
doaj   +1 more source

Auditory Hair Cell Mechanotransduction Channels Dynamically Shape the Mechanical Properties of Their Membrane Environment

Advanced Science, EarlyView.
This work shows, for the first time, that the stereocilia membrane in cochlear hair cells is dynamically regulated by the mechanotransduction channel to impact the membrane mechanical properties. This work provides direct evidence that the opening and closing associated with the MET channel is regulating the membrane viscosity suggesting that the MET ...
Shefin Sam George, Anthony J. Ricci
wiley   +1 more source

Calidad de vida relacionada al sueño de pacientes pediátricos de 3 a 15 años posterior a adenoidectomia o adenotonsilectomia mediante la aplicación del cuestionario OSA-18

Revista GICOS
El desarrollo de la cirugía adenoidea ha mostrado cambios a través del tiempo y es necesario observar el efecto en la calidad de vida relacionada del paciente, por ello, el objetivo de la investigación fue comparar la calidad de vida relacionada al sueño
José Moreno, Miroswa Espinoza
doaj   +1 more source

Promoting gender diversity in the editorial boards of major otorhinolaryngology journals: A call for inclusion and equal representation

Laryngoscope Investigative Otolaryngology, 2023
Objectives The aim of our study was to investigate the representation of women in the editorial boards of otorhinolaryngology journals indexed in the Science Citation Index‐Expanded (SCIE) database.
Asude Ünal, Ayşe Çeçen
doaj   +1 more source

Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Comparative cochlear transcriptomics of noise‐exposed bats (Miniopterus fuliginosus) and mice reveals bat‐specific protection mechanisms for noise‐induced hearing loss (NIHL), identifying Hras as a key hub regulator. Functional studies in mice show hair‐cell‐specific Hras overexpression significantly reduced hair‐cell damage and NIHL by activating the ...
Peng Chen, Chenhao Che, Lingjie Wu, Changjie Sun, Dongming Xu, Qinyang Hua, Yunzhong Zhang, Yi‐Quan Tang, Peng Shi, Shan Sun   +9 more
wiley   +1 more source

DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex

Advanced Science, EarlyView.
This study elucidates how DCAF12 facilitates non‐degradative ubiquitination to stabilize TRiC/CCT, thereby enhancing the folding capacity of chaperonins. This mechanism promotes the maturation of cytoskeletal proteins and activates key oncogenic drivers, including YAP, STAT3, and mTOR, ultimately driving metastatic progression in lung cancer.
Zhenyi Wang, Huanhuan Huang, Kaizong Huang, Xiaowen Cui, Leilei Wu, Renyu Lin, Zhe Zhao, Hua Chen, Cheng Zheng, Weilin Jin, Song Chen, Jiayan Chen, Yaping Xu, Dongping Wei   +13 more
wiley   +1 more source