Results 61 to 70 of about 121,002 (293)
Advanced Science, EarlyView.Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang +14 more
wiley +1 more source
Sialendoscopy in Management of Juvenile Recurrent Parotitis—A Single Centre Experience
Children, 2022 Juvenile recurrent parotitis is a rare inflammatory disease of the parotid gland that shares diverse therapeutic management between institutions.
Luka Pušnik +3 more
doaj +1 more source
Exploring Global Trends in Otorhinolaryngology Research Output [PDF]
, 2022 Background: As an interdisciplinary field, bibliometrics analyses research publications in scientific fields. As a developing medical field, otorhinolaryngology needs to be evaluated from a bibliometric perspective.
Davoud Haseli +11 more
core +1 more source
Advanced Science, EarlyView.FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao +11 more
wiley +1 more source
Disease phenotype-driven alterations in cellular and humoral immunity during chronic rhinosinusitis
Инфекция и иммунитетHuman nasal cavity and paranasal sinuses play a crucial role in the physiological processes in vivo that accounts for the constant attention of doctors of many specialties to the state and pathological changes in the respiratory compartments noted above.
Olga V. Smirnova, A. A. Sinyakov
doaj +1 more source
The 100 Most Cited Turkish Papers in the Otorhinolaryngology Journals of Web of Science
Turkish Archives of Otorhinolaryngology, 2015 Objective:The aim of the study was to analyze the 100 most cited publications with Turkish origin in the Web of Science Otorhinolaryngology (ORL) journals.Methods:The Web of Science database was searched in terms of citations for publications originating
Taner Kemal Erdağ, Gökhan Kurtoğlu
doaj +1 more source
Case Reports in Oncology, 2021 Juvenile nasopharyngeal angiofibroma (JNA) is a relatively uncommon, benign neoplasm of the nasopharynx that can be very difficult to diagnose early due to inconspicuous and seemingly harmless presenting symptoms. Early diagnosis and treatment of JNA are
Zane Blank +4 more
doaj +1 more source
Advanced Science, EarlyView.Accurately detecting diverse same‐locus insertions or deletions (indels) remains challenging. This study reveals the mismatch‐tolerance profile of LwaCas13a and establishes CRISPR‐Scan, which uses a single crRNA to detect multiple same‐locus indels. The one‐pot assay detects nucleophosmin 1 (NPM1) mutant allele frequencies down to 0.01%, agrees with ...
Linlin Bai +13 more
wiley +1 more source
Advanced Science, EarlyView.In hepatocytes, CBX2 promotes H3K4me3 enrichment at the Orai1 promoter to enhance Orai1 transcriptional activation, thereby increasing intracellular Ca2+ levels. The elevated Ca2+ activates the CaMKK2‐AMPK signaling cascade, resulting in ACC phosphorylation and downstream metabolic regulation. This cascade suppresses de novo lipogenesis (Fasn, Acc, Scd‐
Xiang Wei +18 more
wiley +1 more source
Ethical Dilemmas in the Management of Head and Neck Cancers in the Era of the COVID-19 Pandemic
Turkish Archives of Otorhinolaryngology, 2022 Coronavirus disease 2019 (COVID-19) has emerged as an unforeseen challenge for head and neck cancer care providers. A similar challenge is also faced by other oncological fields, but the severity of this challenge is highest in otolaryngology because of ...
Rahim Dhanani +5 more
doaj +1 more source