Results 61 to 70 of about 93,275 (265)

Smoking‐Induced STC2+ Tumor Cells Drive Tumor‐Vascular Crosstalk in Laryngeal Squamous Cell Carcinoma via Spatial and Single‐Cell Transcriptomics

Advanced Science, EarlyView.
This study identifies a smoking‐induced mechanism in LSCC whereby nicotine activates the CHRNA5–JAK2/STAT3 axis to drive STC2 transcription. STC2 upregulates TGFBI, which interacts with endothelial ITGA5 to regulate vascular permeability and promote metastasis.
Yujie Shen, Lianchong Gao, Qiang Huang, Liang Zhou, Chengzhi Xu, Chunping Wu   +5 more
wiley   +1 more source

Tissue engineering in otorhinolaryngology: A knowledge‐based analysis

Laryngoscope Investigative Otolaryngology
Objective To analyze the impact, performance, degree of specialization, and collaboration patterns of the worldwide scientific production on tissue engineering in otorhinolaryngology at the level of countries and institutions.
Javier Padilla‐Cabello, Miguel A. Martin‐Piedra, Antonio Santisteban‐Espejo, Jose A. Moral‐Munoz   +3 more
doaj   +1 more source

PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8+ T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Immunotherapy fails in head and neck squamous cell carcinoma (HNSCC) due to terminally exhausted T (Texterm) cells. Tumor‐derived PD‐L1+ extracellular vesicles promote CD8‐Texterm cells differentiation by upregulating BATF. Stromal Texterm density serves as a potent biomarker for predicting immunotherapy resistance, highlighting a novel EV‐mediated ...
Ruihua Fang, Bixue Huang, Yun Li, Zhimou Cai, Yicheng Deng, Xiaoqing Cen, Wei Sun, Jinhong Zhang, Zhenglin Xu, Wenbin Guo, Yi Lyu, Shiyun Luo, Zhesheng Chen, Kexing Lyu, Weiping Wen, Wenbin Lei   +15 more
wiley   +1 more source

SERS‐AI‐LUA‐Driven Salivary Diagnosis of Head and Neck Cancer Using Graphene‐Assisted Plasmonic Nanocorals

Advanced Science, EarlyView.
The developed graphene‐assisted plasmonic nanocoral platform enables sensitive, label‐free surface‐enhanced Raman scattering analysis of salivary metabolites for head and neck cancer (HNC) detection. When combined with machine learning classification and nonnegative least squares‐based spectral deconvolution, this approach achieves 98% diagnostic ...
Hyo Jeong Seo, Boyou Heo, Jun‐Yeong Yang, Rowoon Park, Sung‐Gyu Park, Jiyoung Yeo, So Hee Park, Chan Kwon Jung, Min‐Young Lee, Jooin Bang, Jun‐Ook Park, Ho Sang Jung   +11 more
wiley   +1 more source

Putting Research Findings into Clinical Practice : Feasibility of integrated evidence-based care pathways in otorhinolaryngology head and neck surgery at Sultan Qaboos University Hospital, Oman

Sultan Qaboos University Medical Journal, 2012
Objectives: A perception exists that clinicians in Oman are reluctant to adopt evidence-based practice (EBP). This pilot study was undertaken to study the feasibility of using EBP pathways at the point of care in otorhinolaryngology head and neck surgery.
Deepa Bhargava, Zainab Al-Lawatia, Rashid Al-Abri, Kamlesh Bhargava   +3 more
doaj  

Turkish Otorhinolaryngology Residents' Participation in Scientific Research Projects: A Survey of Theoretical Knowledge and Attitudes [PDF]

, 2022
Işıl TAYLAN CEBİ, Özlem BAYRAM
openalex   +1 more source

Current Developments and Challenges in the Field of Biohybrid Neural Interfaces—A Scoping Review

Advanced Electronic Materials, EarlyView.
This scoping review explores recent advancements and persistent challenges in biohybrid neural interfaces, which integrate living cells with electronic devices to improve neural communication and implant biocompatibility. The article highlights key innovations, methodological diversity, and translational barriers, providing a comprehensive synthesis ...
Yi‐Lin Yu, Jameel Muzaffar, Veronica Philips, Yun‐Ju Yang, Damiano Giuseppe Barone, George G. Malliaras, Manohar Bance   +6 more
wiley   +1 more source

A Versatile AIEgen for In Situ Monitoring of Entire ApoVs Formation Processes

Aggregate, EarlyView.
This work developed a versatile AIEgen for in situ monitoring of the entire ApoVs formation processes, and demonstrated that ApoVs originate from plasma‐membrane protrusions. ABSTRACT Apoptotic vesicles (ApoVs) are membrane structures formed during cell apoptosis and play crucial roles in homeostasis maintenance, signal transduction, and immune ...
Qiuhua Hao, Nan Sheng, Jie Niu, Chi Li, Fangfang Meng, Xingyu Lyu, Jiaxuan Wang, Zhiqiang Liu, Xiaoqiang Yu   +8 more
wiley   +1 more source

Health‐related quality of life following total minimally invasive, hybrid minimally invasive or open oesophagectomy: a population‐based cohort study

BJS (British Journal of Surgery), EarlyView., 2020
All patients operated for oesophageal cancer in Sweden from 2013 to April 2018 were identified, and 246 patients were recruited to this population‐based nationwide Swedish study. The results show that longitudinal health‐related quality of life after minimally invasive oesophagectomy was similar to that of the open surgical approach.
F. Klevebro, J. H. Kauppila, S. Markar, A. Johar, P. Lagergren   +4 more
wiley   +1 more source

Custom Shape Formation in Continuum Robots Using Compliant Bistable Segments for Medical Applications

Advanced Intelligent Systems, EarlyView.
This article describes the integration of compliant bi‐stability in continuum robots. This integration leads to two variants of compliant bistable mechanism (CBM) integrated continuum robot segments, extending and locking. Results show that when used together, these CBM‐integrated segments allow the continuum robot to form custom shapes.
Muhammad Umer Khan Niazi, Usman Mehmood, Jaesoon Choi, Yoon Se Lee, Youngjin Moon   +4 more
wiley   +1 more source