Results 41 to 50 of about 33,777 (238)

Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex

Nature Communications, 2023
Opioid use disorder (OUD) is influenced by genetic and environmental factors. While recent research suggests epigenetic disturbances in OUD, this is mostly limited to DNA methylation (5mC). DNA hydroxymethylation (5hmC) has been widely understudied.
Gregory Rompala, Sheila T. Nagamatsu, José Jaime Martínez-Magaña, Diana L. Nuñez-Ríos, Jiawei Wang, Matthew J. Girgenti, John H. Krystal, Joel Gelernter, Traumatic Stress Brain Research Group, Yasmin L. Hurd, Janitza L. Montalvo-Ortiz   +10 more
doaj   +1 more source

Erfgoed van de Oorlog, Nederlandse oud-gevangenen van kamp Buchenwald

, 2008
Op de Ettersberg, een forse met bossen begroeide heuvel acht kilometer ten noorden van Weimar, werd in 1937 door de nazi"s het concentratiekamp Buchenwald opgericht. Het werd al snel een van de grootste concentratiekampen van het Derde Rijk.
NIOD Instituut voor Oorlogs-, Holocaust- en Genocidestudies
core   +1 more source

Irregular visits in longitudinal studies: Comparing inverse intensity of visit weighting and imputation in a causal analysis of antidepressant therapeutic treatment

Canadian Journal of Statistics, EarlyView.
Abstract Irregular observation times are common in longitudinal observational studies and can affect causal inferences. We use data from electronic health records of Kaiser Permanente Washington patients in the United States who initiated an antidepressant medication between 2008 and 2018, with a confirming diagnosis of depression. We are interested in
Janie Coulombe, Erica E. M. Moodie, Susan M. Shortreed   +2 more
wiley   +1 more source

Oud-Bijerland, N217 Kwakscheweg (Gemeente Oud-Beijerland). Een karterend booronderzoek. ArGeoBoor rapport 1313.

, 2014
Samenvatting In opdracht van IV-Infra b.v. heeft ArGeoBoor een verkennend en karterend booronderzoek uitgevoerd op langs een deel van de N217 (Kwakscheweg) te Oud-Beijerland. De aanleiding van het onderzoek is de verbreding van de N217.
Beckers, drs. I.S.J. (ArGeoBoor), Nijdam, drs. L.C. (ArGeoBoor), L.C. Nijdam, I.S.J. Beckers   +3 more
core   +1 more source

Addressing in‐hospital substance use: A bioethical evaluation of two possible approaches

Journal of Hospital Medicine, EarlyView.
Abstract Up to 40% of patients with substance use disorder report using non‐prescribed drugs when hospitalized. In‐hospital substance (IHSU) use is associated with poor outcomes and raises safety concerns for healthcare providers. Despite its prevalence, little guidance exists regarding best practices in responding to IHSU.
John C. Messinger, Taylor Baisey, Johanna Sluser, Benjamin A. Barsky, Marlene Martin, Leslie W. Suen   +5 more
wiley   +1 more source

An Analysis of Yorgo Bacanos’ Performance of “Mahur Aranağme”

Konservatoryum
The aim of this study is to reveal the theoretical performative elements behind Yorgo Bacanos’ performance of the aranağme [short instrumental passage between verses in Turkish music] at the end of the song “Gülşen-i Ezhar Açtı Her Yana” that he recorded
Mehmet Alişan Budak, Cenk Güray
doaj   +1 more source

Receipt of medications for opioid use disorder among youth engaged in primary care: data from 6 health systems

Addiction Science & Clinical Practice, 2021
Purpose Little is known about prevalence and treatment of OUD among youth engaged in primary care (PC). Medications are the recommended treatment of opioid use disorder (OUD) for adolescents and young adults (youth).
Sarah M. Bagley, Laura Chavez, Jordan M. Braciszewski, Mary Akolsile, Denise M. Boudreau, Gwen Lapham, Cynthia I. Campbell, Gavin Bart, Bobbi Jo H. Yarborough, Jeffrey H. Samet, Andrew J. Saxon, Rebecca C. Rossom, Ingrid A. Binswanger, Mark T. Murphy, Joseph E. Glass, Katharine A. Bradley, PROUD Collaborative   +16 more
doaj   +1 more source

Quickly identifying people at risk of opioid use disorder in emergency departments: trade-offs between a machine learning approach and a simple EHR flag strategy

BMJ Open, 2022
Objectives Emergency departments (EDs) are an important point of contact for people with opioid use disorder (OUD). Universal screening for OUD is costly and often infeasible. Evidence on effective, selective screening is needed.
Izabela E Annis, Robyn Jordan, Kathleen C Thomas   +2 more
doaj   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Hotter, faster, sicker? Warming shifts the cost of infection from individuals to populations

Journal of Animal Ecology, EarlyView.
This study examines how temperature alters disease impacts across biological scales in a host–pathogen system. We found infected hosts appear healthiest at warm temperatures, yet populations suffer most. This suggests climate warming may intensify disease impacts for populations in ways traditional individual‐level virulence metrics fail to predict ...
Nathan J. Butterworth, Kerri J. Moore, Matthew D. Hall   +2 more
wiley   +1 more source