Results 111 to 120 of about 1,178,335 (287)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The effects of pulse stimulation on biota - Research in relation to ICES advice - Effects on dogfish [PDF]

, 2009
Onderzoek naar het welzijn van hondshaaien bij de vangst. Er is onderzocht of de methode van het gebruik van stroom wel diervriendelijk is.
Haan, D., de, Heul, J.W., van der, Marlen, B., van, Velzeboer, I., Vis, J.W., van de   +4 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Effectiveness of entomopathogenic nematodes in the control of Cydia pomonella larvae in Northern Italy [PDF]

, 2008
Since 2006, a large scale research on the effectiveness of entomopathogenic nematodes (EPN) in the control of codling moth (CM), Cydia pomonella, overwintering larvae has been performed on about 35 ha of pear orchards per year in Emilia-Romagna ...
Caruso, S., Curto, G., Ladurner, E., Reggian, A., Vergnani, S.   +4 more
core  

Out-of-field doses in radiotherapy treatments of paediatric patients

, 2021
Out-of-field doses are delivery to healthy tissues, which may allow the development of second tumours. Its evaluation with MC methods is essential since these doses are inaccurate when calculated by TPSs. The use of IMRT has been discussed, especially in paediatric patients, as it leads to a "bath" of low doses to large volumes of out-of-field tissue ...
openaire   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Editorial: Out-of-field second primary cancer induction: Dosimetry and modelling

Frontiers in Oncology, 2022
Beatriz Sánchez-Nieto, Liliana Stolarczyk, Liliana Stolarczyk, Alexandru Dasu, Alexandru Dasu, Wayne D. Newhauser, Francisco Sánchez-Doblado   +6 more
doaj   +1 more source

A study on out-of-field leakage of an accelerator-based neutron beam for boron neutron capture therapy

Frontiers in Oncology
More and more accelerator-based boron neutron capture therapy (AB-BNCT) facilities are under the construction or commissioning stage, and the neutron beam characteristic measurements at each facility will start soon.
Zhen-Fan You, Chun-Kai Huang, Yen-Wan Hsueh Liu   +2 more
doaj   +1 more source

An Underappreciated Radiation Hazard from High Voltage Electrodes in Vacuum

, 2016
The use of high voltage (HV) electrodes in vacuum is commonplace in physics laboratories. In such systems, it has long been known that electron emission from an HV cathode can lead to bremsstrahlung X-rays; indeed, this is the basic principle behind the ...
DeMille, David, Doyle, John, Gabrielse, Gerald, Kryskow, Adam, Lasner, Zack, Mitchell, Corinne, Panda, Cristian, West, Adam, West, Elizabeth   +8 more
core  

Focal Spot, Fall/Winter 1989 [PDF]

, 1989
https://digitalcommons.wustl.edu/focal_spot_archives/1053/thumbnail ...

core   +1 more source