Results 81 to 90 of about 179,681 (354)

Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5‐Dependent RNA Demethylation

Advanced Science, EarlyView.
FT organoids reverse the aged phenotype of tendon cells, reinstating a fetal‐like state. This breakthrough establishes a potent cell source for tendon tissue engineering, effectively advancing regenerative medicine. ABSTRACT Adult tendon injuries pose a major clinical challenge due to limited self‐repair capacity, resulting in suboptimal regeneration ...
Tian Qin, Aini Pan, Zhuoning Miao, Yanyan Zhao, Xianan Mo, Heng Sun, Chunmei Fan, Junyu Guo, Bingbing Wu, Weiliang Shen, Qiangqiang Zheng, Jun Lu, Xi Jiang, Zi Yin, Xiao Chen   +14 more
wiley   +1 more source

Home care providers to the rescue:a novel first-responder programme [PDF]

, 2015
To describe the implementation of a novel first-responder programme in which home care providers equipped with automated external defibrillators (AEDs) were dispatched in parallel with existing emergency medical services in the event of a suspected out ...
Brøndum, Stig, Christensen, Anette, Hansen, Poul Anders, Hansen, Steen Møller, Kvist, Birgitte, Lauritsen, Torsten L. B., Lindberg, Jan, Lippert, Freddy K., Lyng, Charlotte, Rasmussen, Susanne R., Thomas, Grethe, Torp-Pedersen, Christian   +11 more
core   +3 more sources

The Influence of Timing of Coronary Angiography on Acute Kidney Injury in Out-of-Hospital Cardiac Arrest Patients: A Retrospective Cohort Study. [PDF]

, 2021
Gladys N. Janssens, Joost Daemen, Jorrit S. Lemkes, Eva M. Spoormans, Dieuwertje Janssen, Corstiaan A. den Uil, Lucia S.D. Jewbali, Ton A.C.M. Heestermans, Victor A. Umans, Frank R. Halfwerk, Albertus Beishuizen, Joris Nas, Judith Bonnes, Peter M. van de Ven, Albert C. van Rossum, Paul Elbers, Niels van Royen   +16 more
openalex   +1 more source

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Maximum emergency department overcrowding is correlated with occurrence of unexpected cardiac arrest

Critical Care, 2020
Background Emergency department overcrowding negatively impacts critically ill patients and could lead to the occurrence of cardiac arrest. However, the association between emergency department crowding and the occurrence of in-hospital cardiac arrest ...
June-sung Kim, Hyun-Jin Bae, Chang Hwan Sohn, Sung-Eun Cho, Jeongeun Hwang, Won Young Kim, Namkug Kim, Dong-Woo Seo   +7 more
doaj   +1 more source

A Randomized Controlled Trial of Compression Rates during Cardiopulmonary Resuscitation [PDF]

, 2016
The objective of this study was to compare the efficacy of cardiopulmonary resuscitation (CPR) with 120 compressions per minute (CPM) to CPR with 100 CPM in patients with nontraumatic out-of-hospital cardiac arrest.
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core   +1 more source

Understanding Challenges to High-quality Pediatric Out-of-Hospital Cardiac Arrest Resuscitation Performance [PDF]

, 2023
Amanda O’Halloran, Akira Nishisaki
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Costs related to cardiac arrest management: a systematic review protocol

Systematic Reviews, 2017
Background Each year, about 500,000 people suffer a cardiac arrest (either out-of-hospital or in-hospital) in the USA. Although significant improvements in survival have occurred through the implementation of complex high-quality protocols of care ...
Guillaume Geri, Joshua Gilgan, Carolyn Ziegler, Wanrudee Isaranuwatchai, Laurie J. Morrison   +4 more
doaj   +1 more source

Data quality and 30-day survival for out-of-hospital cardiac arrest in the UK out-of-hospital cardiac arrest registry: a data linkage study [PDF]

, 2017
Objectives The Out-of-Hospital Cardiac Arrest Outcomes (OHCAO) project aims to understand the epidemiology and outcomes of out-of-hospital cardiac arrest (OHCA) across the UK. This data linkage study is a subproject of OHCAO.
Black, Sarah, Booth, Scott J., Brace-McDonnell, Samantha J., Brown, Terry, Gunson, Imogen, HASH(0x55a67fff03b0), Hawkes, C. M., Ji, Chen, Kirby, Kim, Perkins, Gavin D., Rajagopal, Sangeerthana, Siriwardena, A. Niroshan, Spaight, Robert   +12 more
core   +4 more sources