Results 261 to 270 of about 1,096,977 (314)

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

open access: yesAdvanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva   +28 more
wiley   +1 more source

Multi‐Site Transfer Classification of Major Depressive Disorder: An fMRI Study in 3335 Subjects

open access: yesAdvanced Science, EarlyView.
The study proposes graph convolution network with sparse pooling to learn the hierarchical features of brain graph for MDD classification. Experiment is done on multi‐site fMRI samples (3335 subjects, the largest functional dataset of MDD to date) and transfer learning is applied, achieving an average accuracy of 70.14%.
Jianpo Su   +14 more
wiley   +1 more source

Deep Reinforcement Learning-Based Intelligent Water Level Control: From Simulation to Embedded Implementation. [PDF]

open access: yesSensors (Basel)
Cusihuallpa-Huamanttupa K   +6 more
europepmc   +1 more source

Development and content validation of a questionnaire of activities in health promotion for primary and secondary education: PromoACTIVA-CE. [PDF]

open access: yesBMC Public Health
Antón-Solanas I   +9 more
europepmc   +1 more source

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