Results 111 to 120 of about 168,171,873 (264)

Out-of-hospital cardiac arrest outcomes in emergency departments

, 2021
Background: The emergency department (ED) plays an important role in out-hospital-cardiac arrest (OHCA) management. However, ED outcomes are not widely reported. This study aimed to (1) describe OHCA ED outcomes and reasons for ED deaths, and (2) whether
K. Smith (635055), Janet Bray (23288791), P. Cameron (23306080), Judith Finn (23288788), D. Stub (23305006), S. Howell (7655759), S. Bernard (1895089), P. Morley (23365756), K. Kempster (23530021)   +8 more
core  

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Association between direct transport to a cardiac arrest centre and survival following out-of-hospital cardiac arrest: A propensity-matched Aotearoa New Zealand study

Resuscitation Plus
Background and Objectives: Direct transport to a cardiac arrest centre following out-of-hospital cardiac arrest may be associated with higher survival. However, there is limited evidence available to support this within the New Zealand context.
Bridget Dicker, Nick Garrett, Graham Howie, Aroha Brett, Tony Scott, Ralph Stewart, Gavin D. Perkins, Tony Smith, Elena Garcia, Verity F. Todd   +9 more
doaj   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

OUTCOMES OF CARDIOPULMONARY RESUSCITATION (CPR) IN EMERGENCY DEPARTMENT OF AFIC & NIHD. OUT-OF-HOSPITAL VERSUS WITNESSEDCARDIAC ARREST: A COMPARATIVE STUDY

Pakistan Armed Forces Medical Journal, 2017
Objective: To compare the clinical characteristics and outcome of cardiopulmonary resuscitation (CPR)in patients with out-of-hospital cardiac arrest and witnessed-cardiac arrest in Emergency Department of AFIC & NIHD.
Rehana Khadim, Shaheer Farhan, Sadia Saif, Kaneez Fatima Makhdoom, Sabah Khalid, Fauzia Kaleem, Safdar Abbas, Sundus Ejaz   +7 more
doaj   +2 more sources

The quality of care and long-term mortality of out of hospital cardiac arrest survivors after acute myocardial infarction: a nationwide cohort study

The long-terms outcomes of out of hospital cardiac arrest (OHCA) survivors are not well known. Using the Myocardial Ischaemia National Audit Project (MINAP) registry, linked to Office for National Statistics (ONS) mortality data, we analysed 661 326 ...
Banach, Maciej, Hennessy, Tommy, Moledina, Saadiq, Thiele, Holger, Weight, Nicholas, Jia, Haibo, Rashid, Muhammad, Mamas, Mamas A, Siller-Matula, Jolanta M   +8 more
core   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source

Digoxin Alleviates Osteoarthritis by Inhibiting Macrophage Extracellular Trap Formation via Disruption of the LSP1‐SOD1 Interaction

Advanced Science, EarlyView.
Synovial macrophages in osteoarthritis upregulate LSP1, which directly binds and inhibits SOD1, triggering a redox imbalance that activates both NOX and mitochondrial ROS pathways. This cascade drives the release of macrophage extracellular traps (METs), causing chondrocyte damage and disease progression.
Yankai Pan, Xinzhe Feng, Chuanju Liu, Jianfei Tong, Zhi Li, Chenxu Liu, Yutong Dong, Chen Meng, Yihong Xu, Weidong Xu   +9 more
wiley   +1 more source

MicroRNA‐941 Acts as a Novel Prognostic Predictor and Oncogenic Driver in Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
Upregulation of miR‐941 was a promising diagnostic and prognostic biomarker for CRC patients. Inhibition of miR‐941 significantly suppressed CRC cellular events and triggered ferroptosis. The oncogenic functions of miR‐941 were mediated through targeting TRPS1.
Hong Li, Yang Liu, Hua Chen, Jialin Li, Xinchun Li, Yanmin Chen   +5 more
wiley   +1 more source