Results 101 to 110 of about 168,171,873 (264)

Out-of-hospital cardiac arrest : prehospital management [PDF]

, 2018
Sudden out-of-hospital cardiac arrest is the most time-critical medical emergency. In the second paper of this Series on out-of-hospital cardiac arrest, we considered important issues in the prehospital management of cardiac arrest.
Ong, Marcus Eng Hock, Perkins, Gavin D., Gavin D Perkins, Alain Cariou, Cariou, Alain, Marcus Eng Hock Ong   +5 more
core   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Antiarrhythmics in patients with out-of-hospital-cardiac arrest do not improve survival to hospital discharge

Journal of Evidence-Based Healthcare, 2020
Robert Allen, Peter Tepler, Ian deSouza
doaj   +1 more source

Incidence and impact of loss of pulsatility on outcomes after extracorporeal cardiopulmonary resuscitation – A retrospective cohort study

Resuscitation Plus
Aim: Loss of pulsatility, defined as zero pulse pressure, can occur following extracorporeal cardiopulmonary resuscitation (ECPR). The aim of this study was to determine the incidence of loss of pulsatility and assess its association with in-hospital ...
Vinodh Bhagyalakshmi Nanjayya, Alistair Nichol, David M. Kaye, Lloyd Roberts, Kathleen Collins, Jayne Sheldrake, Alisa M. Higgins, Arne Diehl, Julia Coull, Aidan Burrell, Sacha Richardson, Judit Orosz, David Pilcher, Stephen Bernard, Paul Nixon, Vincent Pellegrino, D. James Cooper   +16 more
doaj   +1 more source

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Out-of-hospital cardiac arrest event after cancer diagnosis: a korean metropolitan cohort study

BMC Cancer
Background The importance of assessing out-of-hospital cardiac arrest (OHCA) risk in cancer patients is increasing as cancer incidence rises in aging populations.
Sun Young Lee, Jeong Ho Park, Yoonjic Kim, Jungah Lee, Young Sun Ro, Kyoung Jun Song, Sang Do Shin   +6 more
doaj   +1 more source

Epidemiology and outcomes of out-of-hospital cardiac arrests at sport and recreational events in England, 2015–2022

Resuscitation Plus
Background: Previous studies suggest favourable outcomes for patients experiencing exercise-related out-of-hospital cardiac arrest (OHCA). This study aimed to examine the characteristics and outcomes of OHCAs occurring at sports and recreational events ...
Helen Winterburn, Gavin D. Perkins, Chen Ji, Scott Booth, Adam de Paeztron, Rachael Fothergill, Terry P. Brown   +6 more
doaj   +1 more source

Rapid‐Forming Conductive Antifouling Hydrogel Coating Enables Magnetically Guided Electrochemical POCT for Direct at‑Home Blood Testing

Advanced Science, EarlyView.
The SPG‐MpECis electrochemical POCT platform developed in this study enables direct detection of biomarkers in complex biological samples such as serum and fingerstick blood, demonstrating high concordance with results from clinical reference methods and holding broad potential for at‐home testing applications.
Menghan Li, Kai Su, Ruiwei Hu, Ke Gao, Yuanjie Liu, Lu Zhang, Ningke Fan, Yirong Chen, Wei Cheng, Shijia Ding, Haiping Wu   +10 more
wiley   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Out of hospital cardiac arrest: when to resuscitate

The Pan African Medical Journal, 2019
INTRODUCTION: This study explores why resuscitation is withheld when mobile emergency medical team arrive at the scene of a cardiac arrest.
Saida Zelfani, Hela Manai, Yosra Riahi, Mounir Daghfous   +3 more
doaj   +1 more source