Results 81 to 90 of about 168,171,873 (264)
This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang +10 more
wiley +1 more source
Out-of-hospital cardiac arrest in countries of the Gulf Cooperation Council: A scoping review
Background: Published data are lacking on response to and outcomes of out-of-hospital cardiac arrest in the Middle East. What data there are have not been comprehensively analysed.
Shannon Delport (9791609) +8 more
core +1 more source
Costs related to cardiac arrest management: a systematic review protocol
Background Each year, about 500,000 people suffer a cardiac arrest (either out-of-hospital or in-hospital) in the USA. Although significant improvements in survival have occurred through the implementation of complex high-quality protocols of care ...
Guillaume Geri +4 more
doaj +1 more source
During renal fibrosis, SMAD3 acts as a transcription factor for CRLF1, promoting its expression and secretion. CRLF1 then binds to ITGB1 via an autocrine mechanism, activating the PI3K‐AKT signaling pathway to mediate renal fibrosis. This accelerates the progression from AKI to CKD, highlighting the therapeutic potential of targeting CRLF1 for ...
Chunjie Wang +8 more
wiley +1 more source
Prediction of cognitive dysfunction after resuscitation – a systematic review
Cardiac arrest (CA) due to cardiovascular disease is the leading cause of death in developed countries. It is estimated that over 350,000 people in Europe suffer from out-of-hospital cardiac arrest. According to the literature, the longer the episode of
Wioletta A. Mędrzycka-Dąbrowska +3 more
doaj +1 more source
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong +17 more
wiley +1 more source
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu +16 more
wiley +1 more source
Survival from out-of-hospital cardiac arrest (OHCA) is highly dependent on the time to initial resuscitation efforts. When OHCA occurs in public environments, the probability of CPR-trained responders and proximal AED availability is higher than in ...
Benjamin S. Abella +9 more
doaj +1 more source
Reporting and improving quality of cardiopulmonary resuscitation (CPR) during out of hospital cardiac arrest. [PDF]
Cand.med Jo Kramer-Johansen (f.1969) has studied how quality of CPR can be measured and modified by automated feedback during out of hospital cardiac arrest. The results from 284 episodes of cardiac arrest treated in the ambulance services of Akershus,
Kramer-Johansen, Jo
core +1 more source
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li +9 more
wiley +1 more source

