Results 51 to 60 of about 1,456,776 (335)

From Lab to Market: Paper‐Based CRISPR Diagnostics and Commercialization Pathways

Advanced Sensor Research, EarlyView.
Paper‐based CRISPR diagnostics represents one of the most widely commercialized CRISPR assay technologies, yet challenges remain for broader point‐of‐care use. Abstract The global health landscape is continually challenged by infectious diseases that can swiftly escalate into pandemics, underscoring the need for rapid, accurate, and cost‐effective ...
Selen Dalgan, Qingshan Wei
wiley   +1 more source

Potentiating the Efficacy of mRNA Vaccines through NIR‐II Imaging‐Guided Precise Vaccination

Advanced Science, EarlyView.
A supramolecular strategy is utilized to integrate IR780‐C16 lipids into conventional LNPs, pioneering a novel NIR‐II‐LNPs platform that elucidates the correlations between mRNA vaccines efficacy and vaccination parameters in a non‐invasive approach.
Mengfei Li, Xue Zheng, Xinyang Yu, Shaolong Qi, Shoujun Zhu, Guocan Yu, Songling Zhang   +6 more
wiley   +1 more source

Sustained human outbreak of a new MPXV clade I lineage in eastern Democratic Republic of the Congo

medRxiv
Background: Monkeypox virus (MPXV) attracted global attention in 2022 during a widespread outbreak linked primarily to sexual contact. Clade I MPXV is prevalent in Central Africa and characterized by severe disease and high mortality, while Clade II is ...
E. H. Vakaniaki, C. Kacita, E. Kinganda-Lusamaki, Á. O'toole, T. Wawina-Bokalanga, D. Mukadi-Bamuleka, A. Amuri-Aziza, Nadine Malyamungu-Bubala, Franklin Mweshi-Kumbana, Léandre Mutimbwa-Mambo, Freddy Belesi-Siangoli, Y. Mujula, Edyth Parker, Pauline-Chloé Muswamba-Kayembe, Sabin S Nundu, R. S. Lushima, J. Makangara-Cigolo, N. Mulopo-Mukanya, E. Pukuta-Simbu, P. Akil-Bandali, Hugo Kavunga, Ombotimbe Abdramane, I. Brosius, E. Bangwen, K. Vercauteren, N. A. Sam-Agudu, Edward J. Mills, O. Tshiani-Mbaya, N. Hoff, A. Rimoin, Lisa E. Hensley, J. Kindrachuk, Cheryl Baxter, Tulio de Oliveira, A. Ayouba, M. Peeters, Eric Delaporte, S. Ahuka-Mundeke, E. Mohr, Nancy J Sullivan, J. Muyembe-Tamfum, Jean B Nachega, Andrew Rambaut, L. Liesenborghs, Placide Mbala-Kingebeni   +44 more
semanticscholar   +1 more source

The novel coronavirus (COVID-2019) outbreak: Amplification of public health consequences by media exposure.

Health Psychology, 2020
The 2019 novel coronavirus (COVID-2019) has led to a serious outbreak of often severe respiratory disease, which originated in China and has quickly become a global pandemic, with far-reaching consequences that are unprecedented in the modern era.
Dana Rose Garfin, R. C. Silver, E. A. Holman   +2 more
semanticscholar   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Data-based analysis, modelling and forecasting of the COVID-19 outbreak

medRxiv, 2020
Since the first suspected case of coronavirus disease-2019 (COVID-19) on December 1st, 2019, in Wuhan, Hubei Province, China, a total of 40,235 confirmed cases and 909 deaths have been reported in China up to February 10, 2020, evoking fear locally and ...
C. Anastassopoulou, L. Russo, A. Tsakris, C. Siettos   +3 more
semanticscholar   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

A mathematically assisted reconstruction of the initial focus of the yellow fever outbreak in Buenos Aires (1871) [PDF]

, 2013
We discuss the historic mortality record corresponding to the initial focus of the yellow fever epidemic outbreak registered in Buenos Aires during the year 1871 as compared to simulations of a stochastic population dynamics model.
Fernández, M. L., Otero, M., Schweigmann, N., Solari, H. G.   +3 more
core   +3 more sources

ON AN OUTBREAK OF TYPHOID. [PDF]

The Lancet
n ...
openaire   +2 more sources

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, EarlyView.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source