Results 161 to 170 of about 8,864,759 (285)

The COCOS-IPF core outcome set for idiopathic pulmonary fibrosis/progressive pulmonary fibrosis care: a mixed-method multi-perspective approach. [PDF]

ERJ Open Res
Breuls S, Somogyi V, Schenk S, Toreyin N, Jones S, Galvin L, Boyd J, Tonia T, Delameillieure A, Van Bulck L, Dadaş ÖF, Mogulkoc N, Stenzel N, Kreuter M, Wuyts W, Dobbels F.   +15 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Outcomes following intraoperative rupture of cerebral aneurysms during microsurgical clipping: a systematic review and meta-analysis. [PDF]

Neurosurg Rev
Brekke-Kumley B, Yeganeh K, Fox M, Cler K, Lawton MT, Tayebi Meybodi A.   +5 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Outcome Reporting in Distal Radius Fracture Research: A Systematic Review Across Treatment Modalities. [PDF]

Hand (N Y)
Blum E, Perugini JM, Mologne MS, Dy CJ.
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Relationship Between the American Society of Anesthesiologists Physical Status Classification and Patient Outcomes: A Scoping Review Protocol. [PDF]

Acta Anaesthesiol Scand
Costa LB, Desideri YT, Oliveira ACM, Fabris G, Domingos JVF, Møller AM.   +5 more
europepmc   +1 more source

GrantWatch: Outcomes [PDF]

Health Affairs, 2009
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Development of a lifelong core outcome set for oesophageal atresia ± tracheoesophageal fistula: the OCELOT study. [PDF]

BMJ Open
Thursfield R, Gorst S, Teunisson N, Lansdale N, Faulkner J, Krishnan U, Kovesi T, Slater G, Cullis P, Bray L, Donne A, Teague W, Losty PD, Carr S, Gray V, Gutierrez-Gammino L, Nah SA, Hall NJ.   +17 more
europepmc   +1 more source