Results 171 to 180 of about 14,941,622 (355)

Outcome measurement instruments for the core outcome sets on genital gender-affirming surgery: the GenderCOS project. [PDF]

EClinicalMedicine
Angelini M, Roijer PJ, Vallinga MS, Pidgeon TE, Ceulemans A, Bakker A, Carrière B, Rashid T, Bellringer J, Belinky J, Buncamper M, Morrison SD, Bouman WP, van de Grift TC, Bouman MB, Mullender MG.   +15 more
europepmc   +1 more source

Epidemiology and outcome of zygomycosis: a review of 929 reported cases.

Clinical Infectious Diseases, 2005
M. Roden, T. Zaoutis, Wendy L. Buchanan, T. Knudsen, Tatyana A Sarkisova, R. Schaufele, M. Sein, Tin Sein., C. Chiou, Jaclyn H. Chu, D. Kontoyiannis, T. Walsh   +11 more
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Mind the Gap: Addressing Missing Person Time When Estimating Outcome Incidence in Longitudinal Data. [PDF]

Epidemiology
Rudolph JE, Ross RK, Zalla LC, Mehta SH, Kirk GD, Genberg BL, Lau B, Lesko CR.   +7 more
europepmc   +1 more source

Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the "right stuff"?

Schizophrenia bulletin, 2000
Michael F. Green, R. Kern, D. Braff, J. Mintz   +3 more
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Causes of Unfavorable Outcome in Patients With Aneurysmal Subarachnoid Hemorrhage in Clinical Grade World Federation of Neurosurgical Societies I-III Before Aneurysm Treatment: Impact of Adverse Events. [PDF]

Neurosurg Pract
Baldvinsdóttir B, Kronvall E, Aineskog H, Klurfan P, Alpkvist P, Eneling J, Enblad P, Jakola AS, Svensson M, Lindvall P, Ronne-Engström E, Hillman J, Nilsson OG.   +12 more
europepmc   +1 more source

The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties.

Blood, 1998
By David Grimwade, H. Walker, F. Oliver, K. Wheatley, C. Harrison, G. Harrison, J. Rees, I. Hann, R. Stevens, A. Burnett, A. Goldstone   +10 more
semanticscholar   +1 more source