Results 251 to 260 of about 14,055,650 (415)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Immortal Time Bias in Cohort Studies: A Concept Simply Explained. [PDF]

Indian J Psychol Med
Andrade C.
europepmc   +1 more source

Relationship of Selected Prenatal Factors to Pregnancy Outcome and Congenital Anomalies

, 1965
Sam Shapiro, Lucille J. Ross, Herbert S. Levine   +2 more
openalex   +2 more sources

Predicting the Outcome [PDF]

Journal of the Royal Society of Medicine, 1987
Bryan Jennett, G Teasdale
openaire   +3 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Intracranial pressure dynamics, cerebral autoregulation, and brain perfusion after decompressive craniectomy in malignant middle cerebral artery infarction: is there a role for invasive monitoring? [PDF]

Acta Neurochir (Wien)
Alhamdan M, Hånell A, Howells T, Lewén A, Enblad P, Svedung Wettervik T.   +5 more
europepmc   +1 more source

Outcome and input [PDF]

Developmental Medicine & Child Neurology, 2000
openaire   +3 more sources

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Evaluation of hypotension prediction index software in patients undergoing orthotopic liver transplantation: retrospective observational study

Brazilian Journal of Anesthesiology
Background: Extreme hemodynamic changes, especially intraoperative hypotension (IOH), are common and often prolonged during Liver Transplant (LT) surgery and during initial hours of recovery.
Jacek B. Cywinski, Yufei Li, Lusine Israelyan, Roshni Sreedharan, Silvia Perez-Protto, Kamal Maheshwari   +5 more
doaj  

Easing the Transfer of Students from College to University Programs: How Can Learning Outcomes Help?

, 1969
Irene Carter, James P. Coyle, Donald R. Leslie   +2 more
openalex   +2 more sources