Results 41 to 50 of about 9,721,188 (296)

Cup‐Like Nuclei Is a Hallmark of DUX4/ERG Acute Lymphoblastic Leukemia and Reveals Cytoplasmic Mitochondria Accumulation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille, Hugo Roux, Odile Fenneteau, Aurélie Caye‐Eude, Alexia Kinoo, Yoann Vial, André Baruchel, Marion Strullu, Elodie Lainey, Hélène Cavé   +9 more
wiley   +1 more source

The Integration of the Program Evaluation Standards into an Evaluation Toolkit for a Transformative Model of Care for Mental Health Service Delivery

Journal of MultiDisciplinary Evaluation, 2023
Background: Stepped Care 2.0 (SC2.0) is a transformative model of mental health service delivery. This model was created by Stepped Care Solutions (SCS), a not-for-profit consultancy that collaborates with governments, public service organizations, and ...
M. Elizabeth Snow, Mai Berger, Alexia Jaouich, Mélanie Hood, Amy Salmon   +4 more
doaj   +1 more source

On outcomes [PDF]

Journal of Clinical Epidemiology, 2021
Tovey, David, Tugwell, Peter
openaire   +2 more sources

Genomic correlates of clinical outcome in advanced prostate cancer

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance The genomic landscape of metastatic castration-resistant prostate cancer (mCRPC) has been well-defined, but the association of genomic findings with patient clinical outcomes and with other characteristics including histology and ...
W. Abida, J. Cyrta, G. Heller, D. Prandi, J. Armenia, Ilsa M Coleman, M. Cieslik, M. Benelli, D. Robinson, E. V. Van Allen, A. Sboner, T. Fedrizzi, J. Mosquera, B. Robinson, N. De Sarkar, L. Kunju, S. Tomlins, Yi Mi Wu, Daniel Nava Rodrigues, M. Loda, A. Gopalan, V. Reuter, C. Pritchard, J. Mateo, D. Bianchini, S. Miranda, S. Carreira, P. Rescigno, J. Filipenko, J. Vinson, R. Montgomery, H. Beltran, E. Heath, H. Scher, P. Kantoff, M. Taplin, N. Schultz, J. Debono, F. Demichelis, P. Nelson, M. Rubin, A. Chinnaiyan, C. Sawyers   +42 more
semanticscholar   +1 more source

Genomic Diversity and Clinical Variability in Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma: A Case Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger, Efrat Bar‐Ilan, Victoria Marcu, Evgeny Grishin, Rinat Yacobi, Aviv Barzilai, Hana Golan, Assaf Arie Barg   +7 more
wiley   +1 more source

Comparison between primary care service delivery in Malaysia and other participating countries of the QUALICOPC project: a cross-sectional study

BMJ Open, 2021
Objectives Most countries including Malaysia have set goals to incorporate a strong primary care into the healthcare system. The aim of this study was to evaluate the strength of service delivery process dimensions in Malaysia and compare it with England,
Peter Groenewegen, Ming Tsuey Lim, Su Miin Ong, Seng Fah Tong, Sheamini Sivasampu   +4 more
doaj   +1 more source

Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials.

The Lancet Diabetes and Endocrinology, 2019
BACKGROUND Glucagon-like peptide-1 (GLP-1) receptor agonists differ in their structure and duration of action and have been studied in trials of varying sizes and with different patient populations, with inconsistent effects on cardiovascular outcomes ...
S. Kristensen, R. Rørth, P. Jhund, K. Docherty, N. Sattar, D. Preiss, L. Køber, M. Petrie, J. McMurray   +8 more
semanticscholar   +1 more source

The Combined Effect of Obesity and Contraceptive Use on Pulmonary Embolism in Adolescent Females Residing in the United States

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Combined oral contraceptive (COC) use in obese adult women dramatically increases the relative risk of developing a pulmonary embolism (PE). The risk of a PE in obese adolescent females taking contraceptives is currently unknown. The purpose of this investigation was to determine the effect of body mass index (BMI) and contraceptive
John Puetz, Joanne Salas
wiley   +1 more source

The impact of relaxing restrictions on take-home doses during the COVID-19 pandemic on program effectiveness and client experiences in opioid agonist treatment: a mixed methods systematic review

Substance Abuse Treatment, Prevention, and Policy, 2023
Background The COVID-19 pandemic led to an unprecedented relaxation of restrictions on take-home doses in opioid agonist treatment (OAT). We conducted a mixed methods systematic review to explore the impact of these changes on program effectiveness and ...
Alison Adams, Sarin Blawatt, Tianna Magel, Scott MacDonald, Julie Lajeunesse, Scott Harrison, David Byres, Martin T. Schechter, Eugenia Oviedo-Joekes   +8 more
doaj   +1 more source

Burden of disease, healthcare pathways and costs of cardiovascular high-risk patients with type 2 diabetes: a real world analysis

Global & Regional Health Technology Assessment, 2018
Objective: To estimate the burden of disease and to describe healthcare pathways and costs of type-2diabetes (DMT2) patients at high cardiovascular risk (HRCV).
Carlo Piccinni, Letizia Dondi, Giulia Ronconi, Antonella Pedrini, Nello Martini, Giulio Marchesini   +5 more
doaj   +1 more source