Results 71 to 80 of about 12,191,476 (396)

Outcome Uncertainty and Interestedness in Game-Playing : A Case Study using Synchronized Hex [PDF]

, 2006
Outcome uncertainty is a key-factor to measure the interestedness of a game because people are not attracted by the game where the outcome is easily predictable. To create new variants of classical games is quite easy but to refine solved games, in order
Cincotti, Alessandro, Iida, Hiroyuki
core   +1 more source

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

Nature, 2012
Oestrogen receptor-α (ER) is the defining and driving transcription factor in the majority of breast cancers and its target genes dictate cell growth and endocrine response, yet genomic understanding of ER function has been restricted to model systems ...
R. Stark
semanticscholar   +1 more source

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Level of impaired control predicts outcome of moderation-oriented treatment for alcohol problems [PDF]

, 2005
Aims To examine the ability of the Impaired Control Scale (ICS) to predict outcome of moderation-oriented treatment for alcohol problems and to compare this predictive ability directly with that of a widely used measure of alcohol dependence, the ...
Nick Heather, Heather, Nick, Sharon Dawe, Dawe, Sharon   +3 more
core   +1 more source

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source

Long‐Term Effects of Intensive Lifestyle Intervention on Cardiometabolic Outcomes in Patients With Diabetes in Real‐World Clinical Practice: A 15‐Year Longitudinal Study

Journal of Diabetes
Introduction We previously demonstrated that achieving and maintaining ≥ 7% weight loss at 1 year in patients with diabetes (DM), through multidisciplinary intensive lifestyle intervention (ILI) in real‐world clinical practice, predicts improvement in ...
Abdelrahman Khater, Marwa Al‐Badri, Tareq Salah, Shilton E. Dhaver, Karim Kibaa, Osama Hamdy   +5 more
doaj   +1 more source

A qualitative process evaluation of electronic session-by-session outcome measurement in child and adolescent mental health services [PDF]

, 2014
Background: Regular monitoring of patient progress is important to assess the clinical effectiveness of an intervention. Recently, initiatives within UK child and adolescent mental health services (CAMHS) have advocated the use of session-by-session ...
Marriott, Michael, Goodman, R, Taylor, J, Newell, Karen, Taylor, John, Hall, Charlotte L., Moldavsky, Maria, Charlotte L Hall, Pass, S, Hollis, Chris, Karen Newell, Hall, CL, Hollis, C, Maria Moldavsky, Robert Goodman, Chris Hollis, Moldavsky, M, Sayal, K, Newell, K, Sarah Pass, John Taylor, Kapil Sayal, Sayal, Kapil, Marriott, M, Goodman, Robert, Michael Marriott, Pass, Sarah   +26 more
core   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Heterogeneity in the Global Practice of Central Nervous System Staging in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) is assessed by cell counting and cytomorphology from cerebrospinal fluid (CSF) and is used for treatment stratification worldwide. The ratio of “CNS2” patients in clinical trials ranges from 3% to 40%, with unclear prognostic significance ...
Laura Almási, Bernadett Borbála Huszti, Gábor Barna, Marko Kavcic, Janez Jazbec, Lennart Lenk, Vera Münch, Sophia Polychronopoulou, Ágnes Márk, Maria Thastrup, Lüder H. Meyer, Kjeld Schmiegelow, Cornelia Eckert, Christina Halsey, Dániel J. Erdélyi   +14 more
wiley   +1 more source

Multifetal gestation - Maternal and perinatal outcome of 112 pregnancies [PDF]

, 2002
Purpose: Multifetal pregnancy reduction is a widespread `therapy' to diminish the risk of prematurity and adverse outcome for the survivors in higher order multiple gestation.
Paek, Bettina W., Hepp, Hermann, Janssen, Udo, Strauss, Alexander, Genzel-Boroviczény, Orsolya, Schulze, Andreas   +5 more
core   +1 more source