Results 141 to 150 of about 549,867 (276)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Medical audit and total quality management in health care: a sociological assessment [PDF]
, 1994 Changes in the organization, funding and delivery of health care are affecting health systems in all societies in the search for greater economy, efficiency and effectiveness. The issue of quality is at the forefront of these changes and has been largely
Kinchin-White, James
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
An overview of the nature of the preparation of practice educators in five health care disciplines
, 2005 Practice education is a core element of all educational programmes that prepare health care professionals for academic award and registration to practice.
Mallik, Maggie +4 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
The Clinician's Guide to the Machine Learning Galaxy
Frontiers in Physiology, 2021 Lin Shen +5 more
doaj +1 more source
, 2009 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Previous studies have highlighted the importance of understanding the subjective illness experience.
Norris, Meriel
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