Results 141 to 150 of about 2,144,741 (288)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Linking health and social data to assess care needs and outcomes: Czech experience

European Journal of Public Health
Abstract Background Effective management of health and social care services requires comprehensive and timely data. Czechia has linked its National Health Information System (NHIS) and National Social Information System (NSIS), creating an integrated dataset for evaluation of provided health ...
Benešová, K, Jarkovsk’, J, Kubát, J, Klimeš, D, Soukupová, J, Činčila, B, Petruželka, B, Mužík, J, Dušek, L   +8 more
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Availability of Periodontal Instruments, Procedures, and Specialized Referral in Primary Health Care in Brazil

Pesquisa Brasileira em Odontopediatria e Clínica Integrada
Objective: To analyze the availability of periodontal instruments, services, and specialized referrals in Primary Health Care and compare Brazilian geographical regions.
Manoelito Ferreira Silva-Junior, Elisa Aparecida da Silva Freitas, Fabiana Ribeiro Marques, Mabelle de Freitas Monteiro, Marcia Helena Baldani   +4 more
doaj  

Health Care Assessment of Health Care Delivery and Outcome- A West African Review

Saudi Journal of Medicine, 2019
Lydia T. Cassell, Ayun K. Cassell
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Avaliação da qualidade de assistência primária à saúde em localidade urbana da região sul do Brasil

Revista de Saúde Pública
Foi estudada transversalmente uma amostra de 10% dos pacientes que consultaram em dois Postos de Assistência Primária à Saúde da Cidade de Pelotas (RS), Brasil, com o objetivo de avaliar, qualitativamente, o cuidado à saúde que estava sendo oferecido ...
Iná S. Halal, Felipe Sparrenberger, Anete M. Bertoni, Carla Ciacomet, Carlos E. Seibel, Flávia M. Lahude, Gilson A. Magalhães, Lirio Barreto, Rita C.A. Lira   +8 more
doaj  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Stress hyperglycemia ratio and albumin predict in-hospital outcomes in patients with acute myocardial infarction: a cohort study

Scientific Reports
Elevated stress hyperglycemia ratio (SHR) is a putative risk indicator for acute myocardial infarction (AMI). However, the relationship between SHR, albumin, and subsequent cardiovascular adverse outcomes is less well-established.
Yuxiu Yang, Fei Gao, Xiaoteng Ma, Lixia Yang, Zhijian Wang, Yujie Zhou   +5 more
doaj   +1 more source