Results 191 to 200 of about 2,144,741 (288)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Tradução e validação do questionário OVAMA para língua portuguesa e sua aplicação em pacientes com anomalias vasculares

Revista Brasileira de Cirurgia Plástica
Bruna Caroline da Silva Amaral, Marília Emi Sato Ito, Rebecca Rossener, Ana Paula Schreiner, Dov Charles Goldenberg   +4 more
doaj   +1 more source

Harnessing health economic evaluation for policy and practice. [PDF]

Commun Med (Lond)
Teerawattananon Y, Wang Y, Kc S, Turner HC, Ong BS, Isaranuwatchai W.   +5 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Pediatric Intensive Care Core Outcomes-a modified Delphi consensus process (PIC-CO). [PDF]

Crit Care
Mand N, Lieftüchter V, Westhoff JH, Hort S, Biedermann R, Müller-Brandes C, Merker M, Fuchs H, Cardona F, Beer A, Hoffmann F, Regner F, Lampe S, Pönicke C, Härtel C, Brickmann C, Bruns N, Section of Pediatric Intensive Care and Emergency Medicine of the German Interdisciplinary Association of Intensive Care and Emergency Medicine (DIVI).   +17 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

The Current Landscape of Remote Digital Symptom Monitoring for Patients With Lung Cancer: Scoping Review.

J Med Internet Res
Huang H, Takemura N, Abu-Odah H, Li S, Mao T, Ye Z, Yorke J.   +6 more
europepmc   +1 more source

Feasibility and Acceptability of a Patient- and Family-Oriented Approach to Pain Assessment in the Intensive Care Unit. [PDF]

Nurs Crit Care
Shahid A, Sept BG, Moss SJ, Brundin-Mather R, Krewulak KD, Soo A, Leigh JP, Gélinas C, Fiest KM, Stelfox HT.   +9 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source