Results 211 to 220 of about 2,144,741 (288)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A Personalized, Home-Based, Multidisciplinary Outpatient Clinic for Managing Breathlessness in Chronic Obstructive Pulmonary Disease: Protocol for a Single-Arm, Mixed-Methods Cohort Study.

JMIR Res Protoc
Lee JS, Cochrane B, Smith TA, Smith SM, Foo S, Garcia L, Kemp T.   +6 more
europepmc   +1 more source

STRONGER 60+: study protocol for a mixed-methods randomised controlled trial assessing the clinical effectiveness and delivery of an adapted FINGER model for brain health in primary care. [PDF]

BMJ Open
Welmer AK, Leavy B, Thunborg C, Holleman J, Karlsson P, Hallinder H, Aspö M, Bergström C, Åkesson E, Kulmala J, Kivipelto M.   +10 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Digital and Remote Health for Older Adults in Rural or Underserved Settings: Systematic Review of Clinical, Behavioral, and Implementation Outcomes. [PDF]

JMIR Aging
Beltrán V, Chaple Gil A, Morales-Gómez C, Campos-Bijit V, Contador R, Díaz L, Bustos J, Fernandez E.   +7 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Quality of neonatal intensive care in Africa: a systematic review and meta-analysis. [PDF]

BMC Health Serv Res
Kefale AB, Munea AM, Getahun KA, Yitayal M, Fekadu GA.   +4 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

From Knowledge Graphs to Digital Twins: Perspectives on Modeling Patient Outcomes for Health Care Quality Assessment.

J Med Internet Res
Nitschke AK, Diaz Ochoa JG, Neumaier S, Knott M.   +3 more
europepmc   +1 more source

Outcome measurement instruments for the core outcome sets on genital gender-affirming surgery: the GenderCOS project. [PDF]

EClinicalMedicine
Angelini M, Roijer PJ, Vallinga MS, Pidgeon TE, Ceulemans A, Bakker A, Carrière B, Rashid T, Bellringer J, Belinky J, Buncamper M, Morrison SD, Bouman WP, van de Grift TC, Bouman MB, Mullender MG.   +15 more
europepmc   +1 more source