Results 141 to 150 of about 12,526,027 (293)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Use of artificial intelligence for outcome assessment in pediatric rehabilitation: a scoping review. [PDF]

J Neuroeng Rehabil
Naghdi N, Farhat A, Amara M, Philippopoulos E, Dahan-Oliel N.   +4 more
europepmc   +1 more source

Patient reported outcome assessment must be inclusive and equitable

Nature Medicine, 2018
M. Calvert, S. Cruz Rivera, A. Retzer, S. Hughes, L. Campbell, Barbara Molony-Oates, O. Aiyegbusi, A. Stover, R. Wilson, Christel McMullan, N. Anderson, Grace M. Turner, E. Davies, Rav Verdi, G. Velikova, P. Kamudoni, S. Muslim, Adrian Gheorghe, D. O’Connor, Xiaoxuan Liu, A. Wu, A. Denniston   +21 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Optimizing Precision Oncology: Structural Frameworks for Local MTB Integration and Outcome Assessment. [PDF]

Med Sci (Basel)
Antone NZ, Andreicovici F, Deac AL, Pintican R, Miclaus M, Trifa AP, Catana A, Balacescu O, Vlad C, Achimas-Cadariu P.   +9 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multiple System Atrophy Combined Outcome Assessment (MuSyCA): process, format, and validation plan. [PDF]

Clin Auton Res
Kaufmann H, Palma JA, Millar Vernetti P, Kuijpers M, Nkrumah G, Kang UJ, Ma T, Betensky RA, Claassen DO, Vemuri P, Trujillo P, Siderowf A, Soto C, Feigin AS, Stebbins GT, Lindahl J, Qureshi I, Berger AK, Husnik M, Fanciulli A, Poewe W, Krismer F, Biaggioni I, Singer W, MuSyCA Working Group.   +24 more
europepmc   +1 more source