Results 151 to 160 of about 12,526,027 (293)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Outcome Assessment in Children and Adolescents With Chronic Pain: An International Clinical Practice Survey. [PDF]

Eur J Pain
Miró J, Sánchez-Rodríguez E, Jensen MP, Liossi C, Lord SM, Gobina I, Skidmore N, O'Keeffe M, Walker SM, de la Vega R, Ingelmo P, Koechlin H, Ståhl M, Stinson J, Wicksell RK, Finley GA, Cebrecos J, Goubert L, Reinoso-Barbero F, Rosenberger DC, Pogatzki-Zahn EM.   +20 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Assessing the assessment: a scoping review of the mode of patient-reported outcome assessment in solid cancer clinical trials. [PDF]

Qual Life Res
Hubel N, Krepper D, van der Weijst L, Machingura A, Seidl C, Vorbach SM, Veil M, Giesinger JM, Sztankay M, Kern S, Fitzsimmons D, Kuliś D, Pe M, Holzner B, Lehmann J, EORTC Quality of Life Group.   +15 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Objective outcome assessment in epilepsy surgery using ultralong-term subcutaneous EEG: A case report. [PDF]

Epilepsia Open
Lisy T, Koren JP, Duarte C, Lang C, Pirker S, Tomschik M, Rössler K, Baumgartner C.   +7 more
europepmc   +1 more source

Intradetrusor onabotulinumtoxinA injections for refractory neurogenic detrusor overactivity incontinence: do we need urodynamic investigation for outcome assessment?

BJU International, 2017
M. Koschorke, L. Leitner, H. Sadri, S. Knüpfer, U. Mehnert, T. Kessler   +5 more
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The NAVETA obesity consensus tool: a multidimensional framework for clinical and patient-reported outcome assessment. [PDF]

Front Endocrinol (Lausanne)
Mercadal-Orfila G, Lluch-Taltavull J, Cuatrecasas G, García JM, Maestre-Fullana MA, Herrera-Pérez S.   +5 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source