Results 171 to 180 of about 12,526,027 (293)

Prolapse Quality-of-life Questionnaire is a Reliable Postoperative Outcome Assessment. [PDF]

Gynecol Minim Invasive Ther
Kuroda K, Hamamoto K, Kawamura K, Masunaga A, Horiguchi A, Ito K.   +5 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Clinical Outcome Assessment Tools for Evaluating the Management of Gliomas. [PDF]

Cancers (Basel)
Chakravarti S, Gupta SR, Myneni S, Elshareif M, Rogers JL, Caraway C, Ahmed AK, Schreck KC, Kamson DO, Holdhoff M, Croog V, Redmond KJ, Bettegowda C, Mukherjee D.   +13 more
europepmc   +1 more source

Outcome assessment in Takayasu arteritis.

Rheumatology, 2016
D. Nakagomi, D. Jayne
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Clinical Outcome Assessment Endpoints in Nephrotic Syndrome Drug Development: Research Partner Feedback on Patient-Centered Trial Design. [PDF]

Glomerular Dis
Peipert JD, Kuharic M, Carlozzi NE, Hurt CN, Rahimi AE, Lai JS, Raghunathan T, Hashemi S, Trachtman H, Oni L, Scherr R, Zhai Y, Salmon E.   +12 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Cervical spine chordomas: surgical outcome assessment in a multicenter cohort from the Primary Tumor Research and Outcomes Network. [PDF]

J Neurosurg Spine
Zaldivar-Jolissaint JF, Chu Kwan W, Fisher CG, Rhines LD, Boriani S, Gasbarrini A, Luzzati A, Wei F, Gokaslan ZL, Bettegowda C, Sciubba DM, Lazary A, Kawahara N, Clarke MJ, Barzilai O, Rampersaud YR, Disch AC, Chou D, Shin JH, Hornicek FJ, Laufer I, Sahgal A, Verlaan JJ, Reynolds J, Dea N.   +24 more
europepmc   +1 more source

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

Environmental Toxicology and Chemistry, 2010
G. Ankley, R. S. Bennett, R. Erickson, Dale J. Hoff, M. W. Hornung, Rodney D. Johnson, D. Mount, J. Nichols, C. Russom, P. Schmieder, Jose A. Serrrano, J. Tietge, D. Villeneuve   +12 more
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source