Results 251 to 260 of about 7,854,583 (303)

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

Gamification is not just fun: the effect of gamification design elements on shaping intrinsic motivation and learning persistence. [PDF]

BMC Psychol
Lo CH.
europepmc   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Supporting Visual Working Memory in Healthy Aging: A Review of Current Interventions and Perspectives on Future Approaches. [PDF]

Brain Sci
Tronelli V, Barbon A, Mazza V.
europepmc   +1 more source

Degradation Mechanism of Phosphate‐Based Li‐NASICON Conductors in Alkaline Environment

Advanced Energy Materials, Volume 15, Issue 11, March 18, 2025.
The presence of water in the cathode of a Li‐air battery shifts reactions to produce LiOH, creating a corrosive, alkaline environment. This study investigates the alkaline stability of the common Li‐NASICON solid‐state conductor chemistries through a systematic experimental study combined with computational modeling to understand the degradation ...
Benjamin X. Lam, Zhuohan Li, Tara P. Mishra, Gerbrand Ceder   +3 more
wiley   +1 more source

Beyond Traditional Metrics: A Systematic Review of Spatial and Spatiotemporal Indicators in 5-on-5 Basketball. [PDF]

J Sports Sci Med
Liu Y, Zhang W, Zhang M, Su Q, Xu X.
europepmc   +1 more source

Web-Based Narrative Game Intervention for Initiating Advance Care Planning Among Adults: Exploratory Cross-Sectional Feasibility and Acceptability Study. [PDF]

JMIR Form Res
Iwashiro T.
europepmc   +1 more source

A prospect-theoretic evolutionary game approach for disinformation governance in social-media ecosystems. [PDF]

Sci Rep
Xiaoyu S.
europepmc   +1 more source

Digital tools to enhance adherence to cervical cancer prevention practices: systematic review. [PDF]

Front Public Health
Umbetzhanova A, Kusniyeva A, Derbissalina G, Aigul A, Çaglayan Ç, Tanbayeva G, Koikov V, Toktarova N, Bekbergenova Z.   +8 more
europepmc   +1 more source