Results 51 to 60 of about 1,496,473 (269)

The importance of patient-reported outcomes in clinical trials and strategies for future optimization

open access: yesPatient Related Outcome Measures, 2018
Rebecca Mercieca-Bebber,1 Madeleine T King,2,3 Melanie J Calvert,4,5 Martin R Stockler,1 Michael Friedlander1,6 1NHMRC Clinical Trials Centre, The University of Sydney, Sydney, NSW, Australia; 2Central Clinical School, Sydney Medical School, The ...
Mercieca-Bebber R   +4 more
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Pharmacist Led Telephonic Insulin Titration: A Pilot Study on A1C Control in a Family Medicine Residency

open access: yesPatient Related Outcome Measures
Priya Raghavan,1 Shaunta Chamberlin,1 Robert Eric Heidel,2 Garland Anthony Wilson1 1Department of Family Medicine, UT Health Science Center Graduate School of Medicine, Knoxville, TN, USA; 2Department of Surgery, UT Health Science Center Graduate School ...
Raghavan P   +3 more
doaj  

Outcome measurements in orthopedic

open access: yesIndian Journal of Orthopaedics, 2007
The choice of outcome measure in orthopedic clinical research studies is paramount. The primary outcome measure for a study has several implications for the design and conduct of the study. These include: 1) sample size determination, 2) internal validity, 3) compliance and 4) cost.
Bhandari, Mohit   +2 more
openaire   +3 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

PCORnet’s Collaborative Research Groups

open access: yesPatient Related Outcome Measures, 2018
Mark J Pletcher,1,2 Christopher B Forrest,3 Thomas W Carton4 1Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, 2Division of General Internal Medicine, Department of Medicine, University of California, San ...
Pletcher MJ, Forrest CB, Carton TW
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Comparison of statistical approaches for analyzing incomplete longitudinal patient-reported outcome data in randomized controlled trials

open access: yesPatient Related Outcome Measures, 2018
Ines Rombach,1,2 Crispin Jenkinson,3 Alastair M Gray,1 David W Murray,2 Oliver Rivero-Arias4 1Health Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Oxford, UK; 2Nuffield Department of Orthopaedics, Rheumatology
Rombach I   +4 more
doaj  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

The Impact of Self-Perceived Burden on Loneliness in Stroke Patients: The Mediating Role of Rumination

open access: yesPatient Related Outcome Measures
Xinxin Zhou,1 Lina Guo,2 Yuanli Guo,2 Genoosha Namassevayam,3 Peng Zhao,1 Mengyu Zhang,1 Yuying Xie,1 Yanjin Liu4 1School of Nursing and Health, Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China; 2Department of Neurology ...
Zhou X   +7 more
doaj  

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