Results 241 to 250 of about 10,999,837 (292)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Estimating the effect of hepatitis C infection on multidrug-resistant tuberculosis treatment outcomes under hypothetical interventions on regimen composition and adherence. [PDF]

Am J Epidemiol
LaHood A, Robins J, Stagg HR, Sauer S, Ahmed S, Bastard M, Guglielmetti L, Hewison C, Huerga H, Isani AK, Khan P, Khan U, Lomtadze N, Mamsa S, Melikyan N, Mitnick CD, Rich ML, Seung K, Siddiqui MR, Skrahina A, Stambekova A, Tefera GB, Franke MF.   +22 more
europepmc   +1 more source

Engaging patients throughout the continuum of implementation science and practice: adapted evidence mapping review and practical guide for clinicians and researchers. [PDF]

Health Res Policy Syst
Steeves L, Sampalli S, Ufcrquhart R.
europepmc   +1 more source

UK National Screening Committee position statement on surrogate outcomes in cancer screening trials.

BMJ
Batson S, Hackshaw A, Mackie A, Richards M, Given-Wilson R, Atakpa E, Njagi EN, Shinkins B, Callender T, Hyde C, Visintin C, Thompson D, Cozens E, Evans DG, Hemming K, Payne K, Halligan S, Taylor-Phillips S.   +17 more
europepmc   +1 more source

What outcomes are important to families with a lived experience of stillbirth? A qualitative study to inform the development of a core outcome set for stillbirth care. [PDF]

PLoS One
Bakhbakhi D, Burden C, Davies A, Fraser A, Siassakos D, Lynch M, Timlin L, Duffy JMN, Redshaw M, Dangerfield H, Heazell AEP, Hinton L, iCHOOSE Collaborative Group.   +12 more
europepmc   +1 more source

Voice-assisted artificial intelligence in cardiovascular disease management: a systematic review and meta-analysis protocol. [PDF]

BMJ Open
Issaka A, Maddison R, Lamaro Haintz G, Shariful Islam SM.   +3 more
europepmc   +1 more source