Results 261 to 270 of about 15,903,898 (384)

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 5‐Year Outcomes

New England Journal of Medicine, 2017
P. Schauer, Deepak L. Bhatt, J. Kirwan, K. Wolski, A. Aminian, S. Brethauer, S. Navaneethan, Rishi P. Singh, C. Pothier, S. Nissen, S. Kashyap   +10 more
semanticscholar   +1 more source

Avaliação da qualidade de vida em pacientes com hanseníase: uso do Medical Outcomes Study 36

, 1969
David Lopes Neto, Rogério Olmedija de Araújo, Mayara Elisa Freire Meneghini, Lucila Midori Tsuzuki   +3 more
openalex   +2 more sources

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Treatment outcomes and associated influencing factors among elderly patients with rifampicin-resistant tuberculosis: a multicenter, retrospective, cohort study in China. [PDF]

BMC Infect Dis
Liu H, Zou L, Yu J, Zhu Q, Yang S, Kang W, Ma J, Chen Q, Shi Z, Tang X, Liang L, Tang P, Pan Q, Guo C, Du J, Chang Z, Guo Z, Wu G, Tang S.   +18 more
europepmc   +1 more source

Putting Knowledge to Work: Outcome Performance of the UF/IFAS Welfare to Work Initiative

, 1969
Elizabeth B. Bolton
openalex   +2 more sources

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Assessing the impact of nurses' patient safety competencies on key performance indicators (KPIs) for patient safety outcomes at Tamale Teaching Hospital: the mediating role of leadership and barriers to competency development. [PDF]

BMC Health Serv Res
Ibrahim MM, Abdul-Rahaman F, Sayibu MS, Alhassan DN, Awudu RT, Sisala IM, Wuni A, Abdulai AM.   +7 more
europepmc   +1 more source

HOSPITAL OUTCOMES OF ACUTE MYOCARDIAL INFARCTION IN PATIENTS WITH AND WITHOUT DIABETES MELLITUS

, 1969
Ibrahim Shah, Sherbahadar, Mohammad Hafizullah, Syed Tahir Shah, Abdul Hadi   +4 more
openalex   +2 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source