Results 21 to 30 of about 4,586,853 (323)

Development of a novel patient-reported outcome measure to assess signs and symptoms of COVID-19

Journal of Patient-Reported Outcomes, 2022
Background Given the urgent need for vaccines and treatments for coronavirus disease 2019 (COVID-19), the Symptoms of Infection with Coronavirus-19 (SIC), a comprehensive, patient-reported outcome (PRO) measure of signs and symptoms associated with COVID-
Carla Romano, Sheri Fehnel, Jeffrey Stoddard, Jerald Sadoff, Sandy Lewis, Pauline McNulty, Eric K. H. Chan, Emily Evans, Carol Jamieson, Ashley F. Slagle, Allen Mangel, Kelly McQuarrie   +11 more
doaj   +1 more source

On the Role of Negative Precedent in Legal Outcome Prediction [PDF]

arXiv, 2022
Every legal case sets a precedent by developing the law in one of the following two ways. It either expands its scope, in which case it sets positive precedent, or it narrows it, in which case it sets negative precedent. Legal outcome prediction, the prediction of positive outcome, is an increasingly popular task in AI.
arxiv  

The effect of delaying initiation with umeclidinium/vilanterol in patients with COPD: an observational administrative claims database analysis using marginal structural models

Multidisciplinary Respiratory Medicine, 2018
Background Chronic obstructive pulmonary disease (COPD) is associated with high clinical and economic burden. Optimal pharmacological therapy for COPD aims to reduce symptoms and the frequency and severity of exacerbations.
Ami R. Buikema, Lee Brekke, Amy Anderson, Eleena Koep, Damon Van Voorhis, Lucie Sharpsten, Beth Hahn, Riju Ray, Richard H. Stanford   +8 more
doaj   +1 more source

Key measurement concepts and appropriate clinical outcome assessments in pediatric achondroplasia clinical trials

Orphanet Journal of Rare Diseases, 2022
Background This study aimed to identify fit-for-purpose clinical outcome assessments (COAs) to evaluate physical function, as well as social and emotional well-being in clinical trials enrolling a pediatric population with achondroplasia.
Natalie V. J. Aldhouse, Helen Kitchen, Chloe Johnson, Chris Marshall, Hannah Pegram, Sheryl Pease, Sam Collins, Christine L. Baker, Katherine Beaverson, Chandler Crews, Jill Massey, Kathleen W. Wyrwich   +11 more
doaj   +1 more source

Observational vignette study to examine patient and healthcare provider perceived impact of asthma-related exacerbations in the US

Multidisciplinary Respiratory Medicine, 2019
Background Little is known about how patients and healthcare providers (HCPs) perceive the impact of asthma-related exacerbations. This study examined the impact of asthma-related exacerbations on patients’ lives from these different perspectives ...
Phaedra T. Johnson, Christopher F. Bell, John White, Breanna Essoi, Linda Nelsen, Carlyne M. Averell   +5 more
doaj   +1 more source

Establishing clinically meaningful within-individual improvement thresholds for eight patient-reported outcome measures in people with relapsing-remitting multiple sclerosis

Journal of Patient-Reported Outcomes, 2023
Background As disease-modifying therapies do not reverse the course of multiple sclerosis (MS), assessment of therapeutic success involves documenting patient-reported outcomes (PROs) concerning health-related quality of life, disease and treatment ...
Nupur Greene, Stéphane Quéré, Denise P. Bury, Flora Mazerolle, Manal M’Hari, Angély Loubert, Antoine Regnault, Keiko Higuchi   +7 more
doaj   +1 more source

Outcome Assumptions and Duality Theory for Balancing Weights [PDF]

arXiv, 2022
We study balancing weight estimators, which reweight outcomes from a source population to estimate missing outcomes in a target population. These estimators minimize the worst-case error by making an assumption about the outcome model. In this paper, we show that this outcome assumption has two immediate implications.
arxiv  

Willingness of Greek general population to get a COVID-19 vaccine

Global Health Research and Policy, 2021
Background Epidemiological data indicate that a large part of population needs to be vaccinated to achieve herd immunity. Hence, it is of high importance for public health officials to know whether people are going to get vaccinated for COVID-19.
Georgia Kourlaba, Eleni Kourkouni, Stefania Maistreli, Christina-Grammatiki Tsopela, Nafsika-Maria Molocha, Christos Triantafyllou, Markela Koniordou, Ioannis Kopsidas, Evangelia Chorianopoulou, Stefania Maroudi-Manta, Dimitrios Filippou, Theoklis E. Zaoutis   +11 more
doaj   +1 more source

Discrete Exponential-Family Models for Multivariate Binary Outcomes [PDF]

arXiv, 2022
Studies that collect multi-outcome data such as tobacco and alcohol use are becoming increasingly common. In principle, multi-outcomes studies investigate the correlations between outcomes, including, causal links and/or joint distributions. Although there are many methods for studying multivariate outcomes, significant limitations regarding scale and ...
arxiv  

How to address the challenges of evaluating treatment benefits-risks in rare diseases? A convergent mixed methods approach applied within a Merkel cell carcinoma phase 2 clinical trial

Orphanet Journal of Rare Diseases, 2018
Background Demonstrating treatment benefits within clinical trials in the context of rare diseases is often methodologically and practically challenging. Mixed methods research offers an approach to overcome these challenges by combining quantitative and
Murtuza Bharmal, Isabelle Guillemin, Alexia Marrel, Benoit Arnould, Jérémy Lambert, Meliessa Hennessy, Fatoumata Fofana   +6 more
doaj   +1 more source