Results 61 to 70 of about 4,586,853 (323)
Predicting Adverse Neonatal Outcomes for Preterm Neonates with Multi-Task Learning [PDF]
arXiv, 2023 Diagnosis of adverse neonatal outcomes is crucial for preterm survival since it enables doctors to provide timely treatment. Machine learning (ML) algorithms have been demonstrated to be effective in predicting adverse neonatal outcomes. However, most previous ML-based methods have only focused on predicting a single outcome, ignoring the potential ...
arxiv
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source
Multi-outcome trials with a generalised number of efficacious outcomes [PDF]
arXiv, 2020 Existing multi-outcome designs focus almost entirely on evaluating whether all outcomes show evidence of efficacy or whether at least one outcome shows evidence of efficacy. While a small number of authors have provided multi-outcome designs that evaluate when a general number of outcomes show promise, these designs have been single-stage in nature ...
arxiv
Estimating Counterfactual Matrix Means with Short Panel Data [PDF]
arXiv, 2023 We develop a new, spectral approach for identifying and estimating average counterfactual outcomes under a low-rank factor model with short panel data and general outcome missingness patterns. Applications include event studies and studies of outcomes of "matches" between agents of two types, e.g.
arxiv
King's Law Journal, 2016 While Saskatchewan Federation of Labour v Saskatchewan remains the Supreme Court of Canada’s headline decision for labour law in 2015, Mounted Police Association of Ontario v Canada (Attorney General) arguably further developed the Court’s continuing reappraisal of freedom of association.
openaire +3 more sources
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, EarlyView.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
Health and Quality of Life Outcomes, 2023 Background Psoriasis is a common autoimmune dermatologic condition which has a pronounced negative impact on patient quality of life and disease burden.
Stacie Hudgens +4 more
doaj +1 more source
Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones
FEBS Letters, EarlyView.Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley +1 more source
A qualitative exploration of the patient experience of erosive and non-erosive hand osteoarthritis
Journal of Patient-Reported Outcomes, 2021 Background Many patients with hand osteoarthritis (HOA) experience reduced health-related quality of life. This study sought to better understand the disease and treatment experience of individuals with HOA, explore any differences in experiences between
Charlotte Panter +7 more
doaj +1 more source
Causal inference for binary non-independent outcomes [PDF]
arXiv, 2017 Causal inference on multiple non-independent outcomes raises serious challenges, because multivariate techniques that properly account for the outcome's dependence structure need to be considered. We focus on the case of binary outcomes framing our discussion in the potential outcome approach to causal inference.
arxiv