Results 71 to 80 of about 4,579,575 (247)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A generic and adaptable model of developing, implementing, and maintaining patient-reported outcomes in clinical practice – the AmbuFlex model

Journal of Patient-Reported Outcomes
Background Patient-reported outcomes (PROs) are aspects of health status reported directly by patients. Over the last decade, PROs have been increasingly used in clinical practice.
Liv Marit Valen Schougaard, Anne Jessen, Anne Treschow Phillipsen, Anke de Beijer, Camilla Buur Udbye Agesen, Helle Dahl Harbo, Jonas Hermann Schrøder, Kathrine Hønholt Carlson, Katja Kimose Sloth, Lene Bjerre Graakjaer, Louise Pape Larsen, Mette Roost, Nanna Toxvig Sørensen, Regine Grytnes, Sanne Degn Gjørup, Sidse Østergaard Olesen, Birgith Engelst Grove   +16 more
doaj   +1 more source

Correction to: Psychometric properties of the FACT-M questionnaire in patients with Merkel cell carcinoma

Health and Quality of Life Outcomes, 2019
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Murtuza Bharmal, Fatoumata Fofana, Carla Dias Barbosa, Paul Williams, Lisa Mahnke, Alexia Marrel, Michael Schlichting   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Patient-Reported Burden of Illness in a Prevalent COPD Population Treated with Long-Acting Muscarinic Antagonist Monotherapy: A Claims-Linked Patient Survey Study

Pulmonary Therapy, 2019
Introduction Symptom burden in inadequately controlled chronic obstructive pulmonary disease (COPD) considerably impacts quality of life, healthcare resource utilization (HCRU) and associated costs.
Beth Hahn, Richard H. Stanford, Alyssa Goolsby Hunter, Breanna Essoi, John White, Riju Ray   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Serious treatment-emergent adverse events in chronic low back pain patients treated with buprenorphine or oral opioids: a retrospective commercial claims analysis

Journal of Comparative Effectiveness Research
Aim: Explore the safety of Belbuca (buprenorphine buccal film), buprenorphine transdermal patches and oral opioids for chronic low back pain (cLBP) treatment.
Filip Stanicic, Dimitrije Grbic, Djurdja Vukicevic, Vladimir Zah   +3 more
doaj   +1 more source

Chronic rhinosinusitis with nasal polyps (CRSwNP) symptom verbal response scales: content validity testing for use in adults with CRSwNP

Journal of Patient-Reported Outcomes
Background PRO measures of symptoms in clinical trials have historically utilized visual and numerical scales but verbal descriptors may make it easier for patients to clearly differentiate between response options.
Tom Keeley, Nina Gaw, Waseem Ahmed, Rafael Alfonso-Cristancho, Ana R. Sousa, Katie Forde, Rosie Sharp, Sophie Whyman, Adam Gater   +8 more
doaj   +1 more source