Results 81 to 90 of about 4,586,853 (323)
Simple Sensitivity Analysis for Differential Measurement Error [PDF]
arXiv, 2018 Simple sensitivity analysis results are given for differential measurement error of either the exposure or the outcome. In the case of differential measurement error of the outcome it is shown that the true effect of the exposure on the outcome on the risk ratio scale must be at least as large as the observed association between the exposure and the ...
arxiv
FEBS Letters, EarlyView.α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Journal of Patient-Reported OutcomesBackground PRO measures of symptoms in clinical trials have historically utilized visual and numerical scales but verbal descriptors may make it easier for patients to clearly differentiate between response options.
Tom Keeley +8 more
doaj +1 more source
BMC Musculoskeletal Disorders, 2018 Background The theoretical benefits of a mobile bearing design in Total Knee Arthroplasty (TKA) include increased articular surface conformity with a reduction in both polyethylene wear and implant interface shear.
Richard J. Napier +6 more
doaj +1 more source
Journal of the American College of Cardiology, 2004 We read with interest the report of Kontos et al. ([1][1]), which showed that any detectable troponin I in the serum of patients admitted with chest pain was associated with worse outcomes. We recently reported the results of a similar study involving troponin T levels ([2][2]), and we found ...
Nisha Chandra-Strobos +1 more
openaire +2 more sources
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Diabetology & Metabolic SyndromeBackground Diagnosis of children with type 1 diabetes (T1D) imposes an unprecedented burden on children and their caregivers. Objective To assess the burden of T1D on children and their informal caregivers, both after a recent diagnosis or after a longer
Veleka Allen +6 more
doaj +1 more source
The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum
FEBS Letters, EarlyView.In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti +3 more
wiley +1 more source