Results 51 to 60 of about 327,431 (218)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

The structure of the Tad pilus alignment complex reveals a periplasmic conduit for pilus extension

Nature Communications
The Tad (Tight adherence) pilus is a bacterial appendage implicated in virulence, cell-cell aggregation, and biofilm formation. Despite its homology to the well-characterised Type IV pilus, the structure and assembly mechanism of the Tad pilus are poorly
Sasha L. Evans, Iryna Peretiazhko, Sahil Y. Karnani, Lindsey S. Marmont, James H. R. Wheeler, Boo Shan Tseng, William M. Durham, John C. Whitney, Julien R. C. Bergeron   +8 more
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Der LeGeDe-Prototyp: Zur Erstellung eines korpusbasierten Online-Wörterbuchs zu lexikalischen Besonderheiten im gesprochenen Deutsch. Aktueller Stand und Perspektiven

Lexikos, 2020
The LeGeDe-prototype: The Creation of an Online Dictionary on Lexical Particularities in Spoken German. Current Status and Perspectives. The article focuses on the LeGeDe third-party funded project and the corpus-based lexicographic prototype on the ...
Meike Meliss, Christine Möhrs
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A

Nature Communications
A broad chemical genetic screen in Mycobacterium tuberculosis (Mtb) identified compounds (BRD-8000.3 and BRD-9327) that inhibit the essential efflux pump EfpA.
Nitesh Kumar Khandelwal, Meghna Gupta, James E. Gomez, Sulyman Barkho, Ziqiang Guan, Ashley Y. Eng, Tomohiko Kawate, Sree Ganesh Balasubramani, Andrej Sali, Deborah T. Hung, Robert M. Stroud   +10 more
doaj   +1 more source

Environmentally Sustainable Raised Access Flooring Product Development

Buildings
Raised access floors are nowadays widely used in buildings. A novel raised access flooring product is developed by this research, with a set of sustainable features, including less environmental impact and high strength.
Wenjie Peng, Daizhong Su, Shuyi Wang, Anton Ianakiev   +3 more
doaj   +1 more source

Structural basis of RND-type multidrug exporters

Frontiers in Microbiology, 2015
Bacterial multidrug exporters are intrinsic membrane transporters that act as cellular self-defense mechanism. The most notable characteristics of multidrug exporters is that they export a wide range of drugs and toxic compounds.
Akihito eYamaguchi, Ryosuke eNakashima, Keisuke eSakurai   +2 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source