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Biogenesis of Outer Membrane Proteins

2003
The cell envelope of Gram-negative bacteria consists of two membranes, the inner membrane, which is a phospholipid bilayer, and the outer membrane, which is an asymmetrical bilayer with phospholipids and lipopolysaccharides (LPS) in the inner and outer monolayers, respectively. The membranes are separated by the peptidoglycan-containing periplasm. Both
Tommassen, J.P.M., Voulhoux, J.R.
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Lipoproteins and Their Trafficking to the Outer Membrane

EcoSal Plus, 2019
Lipoproteins are produced by both Gram-positive and Gram-negative bacteria. Once secreted, lipoproteins are quickly acylated, anchoring them into the plasma membrane. Recent work has shown that Gram-positive bacteria are able to generate considerable diversity in the acylation of their lipoproteins, though the mechanisms involved are only ...
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Outer-Membrane Permeability of Bacteria

CRC Critical Reviews in Microbiology, 1986
Gram-negative bacteria evolved to survive under the conditions in which a number of hazardous compounds are abundant. The outer membrane which protects the cell interior acts as a barrier against such hazardous agents, yet the cells must incorporate the chemicals that are essential for the cellular activity.
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Assembly of Bacterial Outer Membrane Proteins

2012
Various methods that are routinely used to study the subcellular localization of membrane proteins in wild-type Gram-negative bacteria fall short in genetic studies addressing the biogenesis of outer membrane proteins (OMPs). Here, we describe three biochemical methods that can be used in such studies to evaluate the proper assembly of OMPs into the ...
Grijpstra, J.   +2 more
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Outer Membrane Proteins

2010
The outer membrane is considered to be a barrier in Gram-negative bacteria. However, bacteria are not autonomous and have to communicate in many ways with their surroundings. This interaction ranges from their association to surfaces, uptake of solutes, and sensing of environmental conditions to export of solutes into attacked cells.
Oliver Mirus   +2 more
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The Outer Membranes of Pseudomonads

2004
The study of bacterial cell surfaces began in 1675 when Leeuwenhoek peering through his microscope wondered what “held [bacteria] together, or what contained them”92. Since that time, our knowledge of cell surfaces, namely the Gram-negative outer membrane, has grown considerably.
Sandeep Tamber, Robert E. W. Hancock
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Leaping into the outer membrane

Trends in Microbiology, 1997
ransport of outer membrane proteins from the inner mem- brane, across the periplasmic space, to the outer membrane in Gram- negative bacteria has long proved an enigma in secretory mechanisms. Clearly, insertion into the first mem- brane occurs via the signal-mediated Sec pathway, but how do these hy- drophobic proteins proceed to their final ...
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The Outer Membrane of Gram-negative Bacteria and the Cytoplasmic Membrane

2004
The major permeability barrier in any membrane is the lipid bilayer structure, and its barrier property is inversely correlated with its fluidity. Bacteria cannot make this membrane much less fluid or it will start to interfere with the normal functions of the membrane proteins, so some bacteria have constructed an additional structure that surrounds ...
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Outer Membrane Proteins

1998
The membrane of Gram-negative bacteria consists of three layers: (i) the cytoplasmic or inner membrane, (ii) the peptidoglycan layer and (iii) the outer membrane (Figure 1). The cytoplasmic membrane consists of a phospholipid bilayer in which proteins are present which can play a role in solute transport, generation of energy and synthesis of cell ...
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The outer membrane of Schistosoma mansoni

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1971
D, Hockley, D, McLaren
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