Results 111 to 120 of about 1,694,595 (291)

Cation-driven envelope dynamics modulate outer membrane vesiculation and extracellular electron transfer in Geobacter

Nature Communications
Geobacter bacteria use conductive pili and redox-active outer membrane vesicles to mediate metal transformations critical to the effectiveness of bioremediation and energy technologies.
Morgen M. Clark, Kazem Kashefi, Gemma Reguera   +2 more
doaj   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Important characteristics of outer membrane vesicles/protein-based vaccines against colibacillosis in broiler chickens.

Important characteristics of outer membrane vesicles/protein-based vaccines against colibacillosis in broiler chickens.
Alessandra Piccirillo (2148712), Helena C. de Carvalho Ferreira (18239418), Ilias Apostolakos (5812853), Giuditta Tilli (16830753), Surya Paudel (662026), Ronald Vougat Ngom (18239415)   +5 more
core   +1 more source

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Application of cryo-electron microscopy for investigation of Bax-induced pores in apoptosis

Nanotechnology Reviews, 2017
Mitochondrial outer membrane permeabilization (MOMP) is a critical step in apoptosis, the molecular mechanisms of which have been a subject of intensive study.
Kuwana Tomomi
doaj   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Vesicle Nucleation Peptide Fusion Induced Extracellular Vesicles Are Distinct From Escherichia coli Outer Membrane Vesicles, and Provide an Enhanced Platform for Protein Production and Purification

Journal of Extracellular Vesicles
Bacterial outer membrane vesicles (OMVs) are nano‐sized, spherical structures released by Gram‐negative bacteria that play diverse roles in bacterial physiology, including communication, nutrient acquisition and host interactions. These vesicles bud from
Bree R. Streather, Tara A. Eastwood, Karen Baker, Mingzhi Liang, Alexandra E. Bailie, Tijn T. van derVelden, Lars J. C. Jeuken, Stanley W. Botchway, Lin Wang, Daniel P. Mulvihill   +9 more
doaj   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Bacterial outer membrane vesicles: A new mechanism for NOD1-dependent responses in epithelial cells

, 2008
Bacterial outer membrane vesicles: A new mechanism for NOD1-dependent responses in epithelial ...
RL Ferrero (15794288), S Girardin (13623139), L Carneiro (13396131), CB Whitchurch (11085333), L Turnbull (11085330), S Firth (13531915), D Philpott (13623136), JK Davies (15794372), M Hutton (13591549), J Mak (14546867), HA Coleman (15791504), J Viala (13623133), HC Parkington (14534543), A Karrar (13623130), M Kaparakis (13623121), L Le Bourhis (13623127)   +15 more
core