Results 131 to 140 of about 163,240 (292)

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Fusobacterium Nucleatum-Derived Outer Membrane Vesicles Promote Immunotherapy Resistance

International Dental Journal
Aim or purpose: To explore whether the F. nucleatum-derived outer membrane vesicles (F.n-OMVs) promote immune escape and malignant phenotype formation of HNSCC.
Li Weiping, Yan Ming, Chen Wantao, Ji Yikang, Wang Xiaoning, Dou Shengjin, Zhang Zhen, Wu Ruoyi, Mao Mengying   +8 more
doaj   +1 more source

Charge-Reversal Instability in Mixed Bilayer Vesicles

, 2000
Bilayer vesicles form readily from mixtures of charged and neutral surfactants. When such a mixed vesicle binds an oppositely-charged object, its membrane partially demixes: the adhesion zone recruits more charged surfactants from the rest of the ...
A. D. Dinsmore, E. J. W. Vervey, H. Aranda-Espinosa, H. Totsuji, I. Rouzina, J. N. Israelachvili, J. Nardi, J. Nardi, J. Nardi, L. D. Landau, L. Guldbrand, L. Ramos, P. Attard, Philip Nelson, R. B. Gennis, R. Kjellander, R. Kjellander, R. Williams, S. A. Safran, S. H. Behrens, S. Hachisu, V. A. Parsegian, V. I. Perel, W. B. Russel, Yi Chen   +24 more
core   +2 more sources

Hierarchical Targeting of TREM2+ Myeloid Cells via Acid‐Triggered OMVs Reprogram Immunosuppression and Suppress Osteolysis in Bone‐Metastatic TNBC

Advanced Science, EarlyView.
This study developed a hierarchical targeting nanoplatform, siTREM2@ETP‐PEOz‐OMVs, against triple‐negative breast cancer (TNBC) bone metastasis. It precisely delivers therapeutic siTREM2 to monocytes/macrophages within the metastatic niche. This intervention dually regulates cell fate: reprogramming immunosuppressive macrophages and inhibiting ...
Fanglu Chen, Yucheng Xue, Xiao Ma, Liang Chen, Zhenxuan Shao, Hangxiang Sun, Haochen Mou, Fangqian Wang, Zilong Li, Yechao Shen, Zhaoming Ye, Xiaohua Yu, Shengdong Wang   +12 more
wiley   +1 more source

Study of macroscopic and microscopic properties of liposomes produced using microfluidic methods [PDF]

, 2019
For the last decades, lipid vesicles or liposomes, vesicles formed by a bilayer of amphiphilic lipids, have been used as a toy model for studying the cell membrane and for applications in cosmetics and drug delivery.
Rojo González, Javier
core  

Diffuse interface models of locally inextensible vesicles in a viscous fluid

, 2013
We present a new diffuse interface model for the dynamics of inextensible vesicles in a viscous fluid. A new feature of this work is the implementation of the local inextensibility condition in the diffuse interface context.
Aland, Sebastian, Egerer, Sabine, Lowengrub, John, Voigt, Axel   +3 more
core   +1 more source

SKOOTS: Skeleton‐Oriented Object Segmentation for Mitochondria in High‐Resolution Cochlear EM Datasets

Advanced Science, EarlyView.
Skeleton‐oriented object segmentation (SKOOTS) introduces a new strategy for 3D mitochondrial instance segmentation by predicting explicit skeletons rather than relying on boundary cues. This approach enables robust analysis of densely packed organelles in large FIB‐SEM datasets.
Christopher J. Buswinka, Richard T. Osgood, Hidetomi Nitta, Artur A. Indzhykulian   +3 more
wiley   +1 more source

Evaluation of the Effect of Outer Membrane Vesicles (EcN) as an Effective and New Postbiotic on Inhibiting the Growth of Staphylococcus Aureus [PDF]

Journal of Mazandaran University of Medical Sciences
Background and purpose: The use of antibiotics is one of the most important ways to deal with bacterial infections. However, the improper of antibiotics and the emergence of drug resistance have compromised the effectiveness of antibiotics ...
Tania MirHosseini, Ava Behrouzi, Sarvenaz Falsafi   +2 more
doaj  

Bordetella Pertussis And Outer Membrane Vesicles

, 2022
Bordetella pertussis is the causative agent of a respiratory infection called pertussis (whooping cough) that can be fatal in newborns and infants. The pathogen produces a variety of antigenic compounds which alone or simultaneously can damage various host cells.
Colak, Cigdem Yilmaz, Tefon Ozturk, Burcu Emine   +1 more
openaire   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source