Results 81 to 90 of about 1,694,595 (291)

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

Trapped lipopolysaccharide and LptD intermediates reveal lipopolysaccharide translocation steps across the Escherichia coli outer membrane [PDF]

, 2015
C.D. is a recipient of the Wellcome Trust Investigator award (WT106121MA). W.W. is supported by Science and Technology Program of Guangzhou, China (201510010040).Lipopolysaccharide (LPS) is a main component of the outer membrane of Gram-negative bacteria,
Dong, H., Li, Xuejun, Wang, W., Gu, Y., Dong, Changjiang, Li, X., Dong, C., Gu, Yinghong, Dong, Haohao, Wang, Wenjian   +9 more
core   +1 more source

Release of Outer Membrane Vesicles from Bordetella pertussis

Current Microbiology, 1999
The aim of the study reported here was to investigate the production of Bordetella pertussis outer membrane vesicles (OMVs). Numerous vesicles released from cells grown in Stainer-Scholte liquid medium were observed. The formation of similar vesicle-like structures could also be artificially induced by sonication of concentrated bacterial suspensions ...
Hozbor, Daniela Flavia, Rodríguez, María Eugenia, Fernández, Julieta, Lagares, Antonio, Guiso, Nicole, Yantorno, Osvaldo Miguel   +5 more
openaire   +3 more sources

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Estimated molecular mass of F. nucleatum fusolisin detected in outer membrane vesicles or in growth medium.

, 2014
aActivity detected only in samples prepared from outer membrane vesicles.Estimated molecular mass of F. nucleatum fusolisin detected in outer membrane vesicles or in growth medium.
Yara Ibrahim (651781), Gilad Bachrach (116639), Graciela Rosen (651784), Amir Eini (651782), Ronit Naor (651783), Shunit Coppenhagen-Glazer (651780), Lior Doron (651779)   +6 more
core   +1 more source

Bacterial outer membrane vesicles suppress tumor by interferon-γ-mediated antitumor response

, 2017
Gram-negative bacteria actively secrete outer membrane vesicles, spherical nano-meter-sized proteolipids enriched with outer membrane proteins, to the surroundings.
Nhung Thi Hong Dinh, Jaewook Lee, Seung-Woo Lee, Seng Jin Choi, Hyun Taek Park, Yong Song Gho, Oh Youn Kim, Ji Hyun Kim   +7 more
core   +2 more sources

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Characterization of Translocation Contact Sites Involved in the Import of Mitochondrial Proteins [PDF]

, 1987
Import of proteins into the mitochondrial matrix requires translocation across two membranes. Translocational intermediates of mitochondrial proteins, which span the outer and inner membrane simultaneously and thus suggest that translocation occurs in ...
Herzog, Volker, Schwaiger, Martin, Neupert, Walter   +2 more
core   +2 more sources

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source

Bacterial Outer Membrane Vesicles Induce Plant Immune Responses

Molecular Plant-Microbe Interactions, 2016
Gram-negative bacteria continuously pinch off portions of their outer membrane, releasing membrane vesicles. These outer membrane vesicles (OMVs) are involved in multiple processes including cell-to-cell communication, biofilm formation, stress tolerance,
Ofir Bahar, Gideon Mordukhovich, Dee Dee Luu, Benjamin Schwessinger, Arsalan Daudi, Anna Kristina Jehle, Georg Felix, Pamela C. Ronald   +7 more
doaj   +1 more source