Results 101 to 110 of about 8,717 (264)

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Revisiting the evolutionary status of massive stars in the central parsec of the Milky Way

Astronomy & Astrophysics
Context. Massive stars and their winds strongly affect their environment. For example, they determine the accretion rate on to the Galactic centre (GC) supermassive black hole Sagittarius A* (Sgr A*).
Gormaz-Matamala A. C., Cuadra J., Kubátová B., Kubát J., Ekström S.   +4 more
doaj   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad, Pouya Metanat, Michael Thomas, Luke W. Bonham, Tyson Lam, Mehmet Kurt, Hong Nguyen, Tara Ellingson, Mauro Zucchelli, Stefano Casagranda, Quin Lu, Andreas M. Rauschecker, Leo Sugrue, Luis E. Savastano, Christopher P. Hess, Kamalini Ranasinghe, S. Andrew Josephson, Bruce L. Miller, Jennifer S. Yokoyama, Gil D. Rabinovici, Peter A. Ljubenkov, Lawren VandeVrede, Kambiz Nael   +22 more
wiley   +1 more source

The drastic impact of Eddington-limit induced mass ejections on massive star populations

Astronomy & Astrophysics
Context. Massive stars emit copious amounts of radiation, profoundly affecting their environment in galaxies and contributing to the reionization of the Universe.
Pauli D., Langer N., Schootemeijer A., Marchant P., Jin H., Ercolino A., Picco A., Willcox R., Sana H.   +8 more
doaj   +1 more source

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

XRISM reveals a variable, multi-phase outflow-inflow structure during the 2024 X-ray obscured outburst of black hole transient V4641 Sgr

Astronomy & Astrophysics
We report the results of a simultaneous X-ray and optical spectroscopy campaign on the Galactic black hole X-ray binary (BH XRB) V4641 Sgr, carried out with XRISM and the Seimei telescope during a low-luminosity phase toward the end of its 2024 outburst.
Parra M., Shidatsu M., Tomaru R., Done C., Muñoz-Darias T., Armas Padilla M., Ogawa S., Marino A., Grollimund N., Corbel S., De la Fuente E., Cheng H., Díaz Trigo M., Fender R., Isogai K., Kobayashi S. B., Motta S. E., Murata K., Negoro H., Safi-Harb S., Suzuki H., Tsuji N., Ueda Y., Wang X., Zhang C., Zhang Y., Zhang Z.   +26 more
doaj   +1 more source

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

JOYS: Unlocking accretion-rate diagnostics for high-mass protostars using JWST/MIRI HI lines

Astronomy & Astrophysics
Context. While many aspects of high-mass star formation have been investigated, the accretion onto the central protostars is one of the most fundamental but less explored physical properties.
Reyes-Reyes S. D., Beuther H., van Dishoeck E. F., Gieser C., Caratti o Garatti A., Tychoniec Ł., Kavanagh P. J., Klaassen P. D., Justtanont K., Francis L., Le Gouellec V. J. M., Devaraj R., Ray T. P., Chen Y., Navarro M. G., Rocha W. R. M., van Gelder M. L.   +16 more
doaj   +1 more source