Results 91 to 100 of about 305,999 (243)

THE IMPLICATIONS OF EXTREME OUTFLOWS FROM EXTREME STARBURSTS [PDF]

, 2016
Interstellar ultraviolet absorption lines provide crucial information about the properties of galactic outflows. In this paper, we augment our previous analysis of the systematic properties of starburst-driven galactic outflows by expanding our sample to
T. Heckman, S. Borthakur
semanticscholar   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

AGN feedback: galactic-scale outflows driven by radiation pressure on dust

, 2015
Galaxy-scale outflows, which are thought to provide the link connecting the central black hole to its host galaxy, are now starting to be observed. However, the physical origin of the mechanism driving the observed outflows, whether due to energy-driving
Fabian, A. C., Ishibashi, W.
core   +1 more source

Direct Evidence for Termination of Obscured Star Formation by Radiatively Driven Outflows in Reddened QSOs [PDF]

, 2011
We present optical to far-infrared photometry of 31 reddened QSOs that show evidence for radiatively driven outflows originating from AGN in their rest-frame UV spectra.
Alexander, Ammons, Andreas Efstathiou, Arav, Arav, Bautista, Becker, Benson, Best, Bower, Bower, Braito, Carol Lonsdale, Carrie Bridge, Casebeer, Chapman, Chartas, Chatterjee, Chung, Ciotti, Colin Borys, Dai, Debuhr, Desai, Dopita, Duncan Farrah, Dunn, Efstathiou, Ellis, Fabian, Farrah, Farrah, Farrah, Farrah, Ferrarese, Ferrarese, Gallagher, Genzel, Gibson, Granato, Granato, Gregg, Hall, Hambrick, Häring, Ilbert, Jahnke, Jarrett, Jose Afonso, Kormendy, Kristen Coppin, Kruegel, Lacy, Le Floc'h, Leighly, Lewis, Lutz, Lutz, Ma, Magorrian, Marchesini, Marconi, Mark Lacy, Menci, Moe, Müller-Sánchez, Nenkova, Ostriker, Patrick B. Hall, Peterson, Proga, Puchwein, Pérez-González, Rakos, Rieke, Roseboom, Rowan-Robinson, Rowan-Robinson, Rupke, Sara Petty, Schawinski, Schmidt, Shields, Shin, Short, Shupe, Silk, Silva, Skrutskie, Snyder, Spoon, Sturm, Tanya Urrutia, Tom Jarrett, Tombesi, Tremaine, Trump, Urrutia, Veilleux, Wagner, Werner, Wright, Wyithe, Xu, York   +104 more
core   +3 more sources

THE ROLE OF COSMIC-RAY PRESSURE IN ACCELERATING GALACTIC OUTFLOWS [PDF]

, 2016
We study the formation of galactic outflows from supernova (SN) explosions with the moving-mesh code AREPO in a stratified column of gas with a surface density similar to the Milky Way disk at the solar circle.
C. Simpson, R. Pakmor, F. Marinacci, C. Pfrommer, V. Springel, S. Glover, P. Clark, Rowan J. Smith   +7 more
semanticscholar   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

PROTOSTELLAR OUTFLOWS AND RADIATIVE FEEDBACK FROM MASSIVE STARS. II. FEEDBACK, STAR-FORMATION EFFICIENCY, AND OUTFLOW BROADENING [PDF]

, 2016
We perform two-dimensional axially symmetric radiation hydrodynamic simulations to assess the impact of outflows and radiative force feedback from massive protostars by varying when the protostellar outflow starts, and to determine the ratio of ejection ...
R. Kuiper, N. Turner, H. Yorke
semanticscholar   +1 more source

Magnetic Propeller Outflows

The Astrophysical Journal, 1999
A model is developed for magnetic `propeller'-driven outflows which cause a rapidly rotating magnetized star accreting from a disk to spin-down. Energy and angular momentum lost by the star goes into expelling most of the accreting disk matter.
Lovelace, R. V. E., Romanova, M. M., Bisnovatyi-Kogan, G. S.   +2 more
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

UNRAVELING THE COMPLEX STRUCTURE OF AGN-DRIVEN OUTFLOWS. I. KINEMATICS AND SIZES [PDF]

, 2016
Outflows driven by active galactic nuclei (AGNs) are often invoked as agents of the long-sought AGN feedback. Yet, characterizing and quantifying the impact on their host galaxies has been challenging. We present Gemini Multi-Object Spectrograph integral
M. Karouzos, J. Woo, Hyun-Jin Bae
semanticscholar   +1 more source