Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec +5 more
wiley +1 more source
Comparison of Outlier Techniques Based on Simulated Data
Adaku C. Obikee +2 more
openalex +2 more sources
DIA-Estimator and Multidimensional Model Misspecifications: GNSS-based Positioning Safety Analysis for UAV. [PDF]
Ciuban S, Teunissen PJG, Tiberius CCJM.
europepmc +1 more source
Controllable Dynamic Mechanical Cell Stimulation using Magnetically Actuated Artificial Cilia
This paper introduces a platform based on magnetic artificial cilia for providing controllable dynamic mechanical stimulation to single cells, suitable for investigating large cell populations and enabling live cell imaging. Proof‐of‐principle experiments show that cell morphology is strongly influenced by the artificial cilia, that cellular forces can
Roel Kooi +5 more
wiley +1 more source
A Variance Shift Model for Detection of Outliers in the Linear Measurement Error Model [PDF]
Babak Babadi +4 more
openalex +1 more source
Outliers (typically) cannot cause type I errors in one-sample/paired t-tests. [PDF]
Wisler A.
europepmc +1 more source
Radiation‐Resistant Aluminum Alloy for Space Missions in the Extreme Environment of the Solar System
A novel ultrafine‐grained aluminum crossover alloy exhibits unprecedented radiation resistance and mechanical stability under extreme irradiation doses up to 100 dpa. The exceptional resilience arises from thermodynamically stable T‐phase precipitates, enabling lightweight structural materials for next‐generation spacecraft and extraterrestrial ...
Patrick D. Willenshofer +9 more
wiley +1 more source
Exploiting the information content of hydrological "outliers" for goodness-of-fit testing
Francesco Laio +2 more
openalex +1 more source
Data gaps and outliers distort critical-slowing-down-based resilience indicators. [PDF]
Liu T +7 more
europepmc +1 more source
An ion‐mediated structural engineering strategy enables versatile modulation of PVA–Alginate hydrogel microstructure. We systematically examine how different ion combinations affect hydrogel mechanical properties and analyte diffusivity. Applying this novel strategy to hydrogel as the outer membrane in an electrochemical glucose biosensor allows ...
Dongwook Lee +14 more
wiley +1 more source

