Results 221 to 230 of about 2,867,772 (256)

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang   +2 more
wiley   +1 more source

UMOD Genotype and Clinical Outcomes in Heart Failure Patients Treated with Loop Diuretics: A UK Biobank Pharmacogenetic Cohort Study

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Uromodulin (UMOD) regulates tubular sodium handling and modulates NKCC2, the molecular target of loop diuretics (LD). Although UMOD variants have been associated with blood pressure and hypertension, their pharmacogenetic relevance in heart failure (HF) remains unknown.
Reinhold Kreutz   +5 more
wiley   +1 more source

Urinary incontinence in Ugandan gynecologic outpatient clinics: Prevalence, clinical types, and associated factors. [PDF]

open access: yesPLOS Glob Public Health
Katongole J   +6 more
europepmc   +1 more source

Challenges and Barriers in Pediatric to Adult Transition in Chronic Pulmonary Diseases in Italy: A Nationwide Survey.

open access: yesRespiration
Mazzoni M   +11 more
europepmc   +1 more source

Self-Pay Prices and Financial Assistance Programs for Urology Appointments.

open access: yesJAMA Netw Open
Hsiang W   +8 more
europepmc   +1 more source

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