Results 181 to 190 of about 6,186,359 (298)

Phenotypic Plasticity in <i>Arabidopsis thaliana</i> Is Fitness-Neutral, and Costs Are Lacking Across Experimental Environments. [PDF]

Ecol Evol
Shamsid-Deen ML, Whitney KD.
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Reset-free DNA logic circuits for real-time input processing and memory. [PDF]

Sci Adv
Sim J, Kim T, Kim W, Jeong S, Choi E, Kim S, Choi H, Yim SS, Choi Y.   +8 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

A Compact SLED Light Source Driver Module for Optical Coherence Tomography Applications. [PDF]

Sensors (Basel)
Cao Y, Liu F, Mei J, Liu Q, Chen B.
europepmc   +1 more source

Output waveforms analysis of CSI with sinusoidal outputs.

IEEJ Transactions on Industry Applications, 1989
Shigeta Ueda, Mitsuyuki Hombu, Akiteru Ueda   +2 more
openaire   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Coherent control of optical spin-orbit interactions. [PDF]

Sci Adv
Yang H, Tu K, Chen Z, Hong Y, Tang J, Zheng H, Zhong Y, Yu J, Chen Z, Zhu W.   +9 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Self-Powered Ultrastretchable Microstructured Intelligent Sensing Technology Based on Tactile Perception of Limb Movement. [PDF]

ACS Omega
Zhao D, Jiang X, Xu H, Wu J, Lin Z, Guo Q.   +5 more
europepmc   +1 more source